Reduction and cyclization in biotransformation of carbonyl compounds by cultured cells of Taxus species
Por:
Sandoval, C, Mendez, JM, Sanchez-Obregon, R, Alpizar, CB, Barrios, H
Publicada:
1 ene 2009
Resumen:
Cultured plant cells from Taxus brevifolia Nutt and Taxus globosa Schltdl were investigated as biocatalysts using exogenous substrates. Production of highly specific metabolites by these species prompted us to analyse their synthetic potential. Whole cells suspensions have the capacity to chemoselectively reduce ethyl acetoacetate to ethyl 3-hydroxybutyrate, chemo-and stereoselectively reduce rac-2-benzoylcyclohexanone to (1R, 2S)- and (1S, 2S)-2-hydroxycyclohexylphenylmethanones, and to cyclize N-phthaloyl-L-glutamine to thalidomide.
Filiaciones:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Quim Organ, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Inst Quim, Dept Sintesis Organ, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Inst Quim, Dept Quim, Mexico City 04510, DF, Mexico
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