Renoprotective mechanisms of soy protein intake in the obese Zucker rat
Por:
Trujillo, J, Cruz, C, Tovar, A, Vaidya, V, Zambrano, E, Bonventre, JV, Gamba, G, Torres, N, Bobadilla, NA
Publicada:
1 nov 2008
Resumen:
Trujillo J, Cruz C, Tovar A, Vaidya V, Zambrano E, Bonventre JV, Gamba G, Torres N, Bobadilla NA. Renoprotective mechanisms of soy protein intake in the obese Zucker rat. Am J Physiol Renal Physiol 295: F1574-F1582, 2008. First published September 24, 2008; doi:10.1152/ajprenal.90385.2008. -We previously showed that long- term consumption of a soy protein diet (SoyP) reduces renal damage in obese Zucker (ObeseZ) rats by restoring urinary NO(2) and NO(3) excretion (UNO(2)/NO(3)V), suggesting that nitric oxide (NO) deficiency may contribute to the renal progression observed in this model. In addition, there is compelling evidence that hyperleptinemia produced deleterious effects on the kidney through its interaction with the short leptin receptor (ObRa). This study was designed to evaluate the contribution of the NO/endothelial NO synthase (eNOS) system, renal oxidative stress, and ObRa expression to the renoprotection conferred by the consumption of a SoyP in ObeseZ rats. Ten lean and t
Filiaciones:
Trujillo, J:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City 14000, DF, Mexico
Cruz, C:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City 14000, DF, Mexico
Gamba, G:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City 14000, DF, Mexico
Bobadilla, NA:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City 14000, DF, Mexico
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