Metabolic profiling of the Mexican anxiolytic and sedative plant Golphimia glauca using nuclear magnetic resonance spectroscopy and multivariate data analysis
Por:
Cardoso-Taketa A.T., Pereda-Miranda R., Choi, YH, Verpoorte R., Villarreal M.L.
Publicada:
1 ago 2008
Resumen:
Galphimia glauca is popularly employed in Mexico for the treatment of central nervous system disorders. Pharmacological and phytochemical studies have resulted in the identification of the anxiolytic and sedative principle consisting of a mixture of nor-secofriedelanes, named the galphimine series (1-9). These active constituents were found in plants collected in the vicinity of a restricted region in Central Mexico, where this species is abundant. A metabolic profiling carried out by means of (1)H-NMR spectroscopy and multivariate data analysis was applied to crude extracts from wild plant populations, collected from six different locations as a quality control assessment, in order to differentiate their chemical profile. Principal component analysis (PCA) of the (1)H-NMR spectra revealed clear variations among the populations, with two populations out of the six studied manifesting differences, when the principal components PC-1 and PC-2 were analyzed. These two PCs permitted the dif
Filiaciones:
Cardoso-Taketa A.T.:
Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
Pereda-Miranda R.:
Univ Nacl Autonoma Mexico, Dept Farm, Fac Quim, Mexico City 04510, DF, Mexico
Verpoorte R.:
Division of Pharmacognosy, Institute of Biology, Leiden University, Leiden, Netherlands
Villarreal M.L.:
Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001 Col. Chamilpa, Cuernavaca Morelos 62210, Mexico
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