Selective iNOS inhibition reduces renal damage induced by cisplatin
Por:
Chirino Y.I., Trujillo J., Sánchez-González D.J., Martínez-Martínez C.M., Cruz C., Bobadilla N.A., Pedraza-Chaverri J.
Publicada:
4 ene 2008
Categoría:
Toxicology
Resumen:
Cisplatin is a chemotherapeutic agent used in the treatment of several cancer tumors; however, nephrotoxicity has restricted its use. Reactive oxygen species and peroxynitrite, which is formed by the reaction between superoxide anion and nitric oxide (NO degrees), are implicated in cisplatin-induced nephrotoxicity. In contrast, both toxic and beneficial effects of NO degrees have been suggested in cisplatin-induced nephrotoxicity. Therefore, nowadays the role of NO degrees in this experimental model remains controversial. The aim of the present work was to elucidate the role of NO degrees in cisplatin-induced renal damage using N-[3-(aminomethyl)benzyl]acetamidine (1400W), a selective and irreversible inhibitor of iNOS. The mRNA levels of iNOS were increased in cisplatin-treated rats. The administration of 1400W reduced the cisplatin induced histological damage, renal dysfunction (increase in proteinuria and kidney injury molecule expression and decrease in creatinine clearance), tubul
Filiaciones:
Chirino Y.I.:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Mexico City 04510, DF, Mexico
Trujillo J.:
Univ Nacl Autonoma Mexico, Unidad Fisiol Mol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Sánchez-González D.J.:
Departamento de Biología Celular, Escuela Médico Militar, Universidad del Ejército y Fuerza Aérea, Mexico
Martínez-Martínez C.M.:
Departamento de Biología Celular, Escuela Médico Militar, Universidad del Ejército y Fuerza Aérea, Mexico
Cruz C.:
Departamento de Nefrologia, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Mexico
Bobadilla N.A.:
Univ Nacl Autonoma Mexico, Unidad Fisiol Mol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Pedraza-Chaverri J.:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Mexico City 04510, DF, Mexico
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