Molecular markers: an important tool in the diagnosis, treatment and epidemiology of invasive aspergillosis
Por:
León M.G.F.-D., Acosta-Altamirano G., Duarte-Escalante E., Martínez-Hernández J.E., De Los Ángeles Martínez-Rivera M., Del Rocío Reyes-Montes M.
Publicada:
1 ene 2014
Categoría:
Surgery
Resumen:
Increase in the incidence of invasive aspergillosis has presented a
difficult problem for management of patients with this infection due to
its high rate of mortality, limited knowledge concerning its diagnosis,
and therapeutic practice. Difficulty in management of patients with
aspergillosis initiates with detection of the fungus in the specimens of
immunosuppressed patients infected with Aspergillus fumigatus. In
addition, difficulty exists in terms of the development of resistance to
antifungals as a consequence of their indiscriminate use in prophylactic
and therapeutic practice and to ignorance concerning the epidemiological
data of aspergillosis. With the aim of resolving these problems,
molecular markers are currently used with specific and accurate results.
However, in Mexico, routine use of molecular markers has not yet been
implemented in intrahospital laboratories despite the fact that these
molecular markers have been widely reported in the literature. It is
necessary for use of these markers to be validated and standardized to
ensure that the results obtained in any laboratory would be reliable and
comparable. In the present review we present an update on the usefulness
of molecular markers in the accurate identification of A. fumigatus,
detection of resistance to antifugal triazoles, and epidemiological
studies for establishing the necessary measures for prevention and
control of aspergillosis.
Filiaciones:
León M.G.F.-D.:
División de Investigación, Hospital Juárez de México, México, DF, Mexico
Acosta-Altamirano G.:
División de Investigación, Hospital Juárez de México, México, DF, Mexico
Duarte-Escalante E.:
Departamento de Microbiología y Parasitología, Facultad de Medicina, UNAM, Ciudad Universitaria 3000, 04510 México DF, Mexico
Martínez-Hernández J.E.:
Departamento de Microbiología y Parasitología, Facultad de Medicina, UNAM, Ciudad Universitaria 3000, 04510 México DF, Mexico
De Los Ángeles Martínez-Rivera M.:
Laboratorio de Micología Médica, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, IPN, México DF, Mexico
Del Rocío Reyes-Montes M.:
Departamento de Microbiología y Parasitología, Facultad de Medicina, UNAM, Ciudad Universitaria 3000, 04510 México DF, Mexico
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