Anti-inflammatory, antioedema and gastroprotective activities of Aristotelia chilensis extracts, part 2 [Anti-inflammatory Activity of Aristotelia chilensis Mol. (Stuntz) (Elaeocarpaceae)]
Por:
Céspedes C.L., Alarcon J., Avila J.G., El-Hafidi M.
Publicada:
1 ene 2010
Resumen:
Context: "Chilean black-berry" Aristotelia chilensis is a wild fruit that grows in Southern Chile. This fruit possesses a strong antioxidant activity and is commonly used in foods and beverages in Chile. Objective: The gastroprotective and anti-inflammatory activities of the extracts, fractions and subfractions as carrageenan- induced paw oedema in rats are reported here for the first time. Materials and methods: Extracts, fractions, subfractions and several compounds were used for measuring the effects in carrageenan-induced paw oedema inflammation of rat model and the gastroprotective activity was analyzed. Results: The results showed that extract B, fraction F-4, and ovatifolin, quercetin, myricetin, luteolin and diosmetin used as pattern compounds were the most active samples together with those subfractions rich in aglycone and phenolic compounds. Thus, SF11-SF15, SF16-SF20, and SF21-SF25 showed the best subfractions inhibitors in similar form to indomethacin, a known selective COX inhibitor. Results demonstrated that these samples strongly inhibited the carrageenan-induced inflammation in paw of the rat oedema model. Discussion and conclusion: These findings demonstrate that the fruits and their constituents of A. chilensis are anti-inflammatory and gastroprotective and thus have great potential as nutraceuticals. © 2010 Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas.
Filiaciones:
Plant Biochemistry and Phytochemical Ecology Laboratory, Department of Basic Sciences, University of Bío-Bío, Chillán, Chile
Phytochemical Laboratory, UBIPRO, FES-Iztacala, UNAM, Mexico
Department of Biochemistry, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1, Sección XVI, Tlalpan, 14080, México D.F, Mexico
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