Surfactant protein genetic marker alleles identify a subgroup of tuberculosis in a Mexican population
Por:
Floros J., Lin H.-M., Garcia A., Salazar M.A., Guo X., Diangelo S., Montano M., Luo J., Pardo A., Selman M.
Publicada:
1 ene 2000
Resumen:
Pulmonary surfactant and its components are essential for normal lung function and are involved in local host defense. Surfactant protein (SP)-A and SP-D bind to and modulate phagocytosis of Mycobacteriurn tuberculosis by macrophages. Frequency comparisons of SP marker alleles in tuberculosis patients and healthy control subjects (tuberculin-skin test positive or general population) were performed. Regression analyses of the tuberculosis and the tuberculin-skin test positive groups revealed, on the basis of odds ratios, tuberculosis susceptibility (DA11-C and GATA-3) and protective (AAG-2) marker alleles. Similarly, between tuberculosis patients and general population control subjects, susceptibility 1A3, 6A4, and B1013-A and protective AAGG-1, and AAGG-7 marker alleles were observed. Moreover, interactions were seen between alleles 6A2 and 1A3 (P = .0064) and between 1A3 and B1013-A (P = .036). The findings indicate a possible involvement of SP alleles in tuberculosis pathogenesis.
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