Effect of Tapentadol on Dogs’ Minimum Alveolar Concentration (MAC) of Isoflurane
Por:
Ibancovichi-Camarillo J.A., Chávez-Monteagudo J.R., De Paz-Campos M.A., Gutiérrez-Olvera L., Sumano-López H.S.
Publicada:
1 ene 2025
Resumen:
To evaluate the effect of oral administration of 10 mg kg-1 tapentadol on dogs’ minimum alveolar concentration of isoflurane. The MAC of isoflurane was determined in seven dogs without previous medication (Group MACISO) and 2 h 30 min after the administration of 10 mg kg-1 of tapentadol orally (Group MACISO+TAP). The MAC was determined by pinching the fourth finger of the pelvic limb. Data normality was analyzed using the Shapiro–Wilk test. Student’s t-test was used to evaluate the effect of tapentadol on isoflurane MAC and cardiovascular variables. The minimum alveolar concentration obtained in the Group MACISO was 1.52 ± 0.02%, and in the Group MACISO+TAP, it was 1.47 ± 0.03%, observing a significant statistical difference between groups (p = 0.01). The reduction in the MAC caused by administering 10 mg kg-1 of Tapentadol was 3.29%. No statistically significant differences were observed when the heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were compared between groups. The oral administration of 10 mg kg-1 tapentadol reduces dogs’ minimum alveolar concentration of isoflurane without alterations in the heart rate and systemic blood pressure. © 2025 by the authors.
Filiaciones:
Ibancovichi-Camarillo J.A.:
Anestesiología y Analgesia, Facultad de Medicina Veterinaria, Universidad Autónoma del Estado de México, UAEMex, Toluca, 50000, Mexico
Chávez-Monteagudo J.R.:
Departamento de Ciencias Pecuarias, Facultad de Estudios Superiores Cuautitlán, Hospital de Pequeñas Especies, Universidad Nacional Autónoma de México, UNAM, Cuautitlán Izcalli, 54740, Mexico
De Paz-Campos M.A.:
Departamento de Ciencias Biológicas, Facultad de Estudios Superiores Cuautitlán, Hospital de Pequeñas Especies, Universidad Nacional Autónoma de México, UNAM, Cuautitlán Izcalli, 54740, Mexico
Gutiérrez-Olvera L.:
Departamento de Fisiología y Farmacología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, UNAM, Ciudad de México, 04510, Mexico
Sumano-López H.S.:
Departamento de Fisiología y Farmacología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, UNAM, Ciudad de México, 04510, Mexico
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