International prevalence patterns of low eGFR in adults aged 18-60 without traditional risk factors from a population-based cross-sectional disadvantaged populations eGFR epidemiology (DEGREE) study
Por:
Rutter C.E., Tatapudi R.R., Hathaway M.H., O'Callaghan-Gordo C., Chulasiri P., Ruwanpathirana T., Gonzalez-Quiroz M., Correa-Rotter R., Aekplakorn W., Anand S., Aragón A., Bernabe-Ortiz A., Biggeri A., Burdmann E., Caplin B., Catelan D., Cooper P.J., Cortés S., Crampin A.C., de Santiago M., Dhimal M., Doccioli C., Dorevitch S., Ferreccio C., Glaser J., Granadillo E., Gualan M., Gummidi B., Gunawardena N., Hamilton S., Hathaway M., Jakobsson K., Jarhyan P., Jha V., John O., Johnson R.J., Kaur P., Kitiyakara C., Kongtip P., Kromhout H., Levin A., Madero M., McLean E., Miranda J.J., Mkandawire J., Mohan S., Murali S., Nair D., Nakanga W., Nitsch D., Njoroge M., Nyirenda M., Pearce N., Poudyal A., Prabhakaran D., Prasad N., Quirós-Alcalá L., Remuzzi G., Robertson S., Rohloff P., Romero-Sandoval N., Ruiz-Alejos A., Sakthivel M., Saran R., Senanayake S., Shaw L., Singh A., Smeeth L., Sotomayor C., Tuiz E., Venkateshmurthy N.S., Venugopal V., Wickramasinghe S.C.
Publicada:
1 ene 2025
Resumen:
The disadvantaged populations eGFR (estimated glomerular filtration rate) epidemiology (DEGREE) study was designed to gain insight into the burden of chronic kidney disease (CKD) of undetermined cause (CKDu) using standard protocols to estimate the general-population prevalence of low eGFR internationally. Therefore, we estimated the age-standardized prevalence of eGFR under 60 ml/min per 1.73m2 in adults aged 18-60, excluding participants with commonly known causes of CKD; an ACR (albumin/creatinine ratio) over 300 mg/g or equivalent, or self-reported or measured (HT) hypertension or (DM) diabetes mellitus, stratified by sex and location. We included population-representative surveys conducted around the world that were either designed to estimate CKDu burden or were re-analyses of large surveys. There were 60,964 participants from 43 areas across 14 countries, with data collected 2007- 2023. The highest prevalence was seen in rural men in Uddanam, India (14%) and Northwest Nicaragua (14%). Prevalence above 5% was generally only observed in rural men, with exceptions for rural women in Ecuador (6%) and parts of Uddanam (6%?8%), and for urban men in Leon, Nicaragua (7%). Outside of Central America and South Asia, prevalence was below 2%. Our observations represent the first attempts to estimate the prevalence of eGFR under 60 without commonly known causes of CKD around the world, as an estimate of CKDu burden, and provide a starting point for global monitoring. It is not yet clear what drives the differences, but available evidence supports a high general-population burden of CKDu in multiple areas within Central America and South Asia, although the possibility that unidentified clusters of disease may exist elsewhere cannot be excluded. © 2024 International Society of Nephrology
Filiaciones:
Rutter C.E.:
Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom
London School of Hygiene and Tropical Medicine, United Kingdom
Tatapudi R.R.:
The Apollo University, Andhra Pradesh, Chittoor, India
The Apollo University, India
Hathaway M.H.:
Division of Environmental and Occupational Health Sciences, School of Public Health, University of Illinois Chicago, Chicago, IL, United States
O'Callaghan-Gordo C.:
Faculty of Health Sciences, Universitat Oberta de Catalunya, Barcelona, Spain
Barcelona Institute of Global Health (ISGlobal), Barcelona, Spain
Universitat Pompeu Fabra, Barcelona, Spain
Networking Centre of Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Open University of Catalonia, Spain
Chulasiri P.:
Ministry of Health, Sri Lanka
Ruwanpathirana T.:
Ministry of Health, Sri Lanka
Epidemiology Unit, Ministry of Health, Sri Lanka
Gonzalez-Quiroz M.:
Department of Environmental and Occupational Health, UT School of Public Health San Antonio, The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States
Centre for Kidney and Bladder Health, University College London, London, United Kingdom
Center for Indigenous Health Research, Wuqu’ Kawoq - Maya Health Alliance, Chimaltenango, Guatemala
Wuqu’ Kawoq Maya Health Alliance, Guatemala
The University of Texas Health Science Centre at San Antonio, USA Wuqu’ Kawoq Maya Health Alliance, Guatemala
University College London
Correa-Rotter R.:
Department of Nephrology and Mineral Metabolism, Salvador Zubiran National Institute of Health Sciences and Nutrition, Mexico City, Mexico
National Autonomous University of Mexico, Mexico
Aekplakorn W.:
Ramathibodi Hospital, Thailand
Anand S.:
Stanford University, United States
Aragón A.:
Center for Indigenous Health Research, Wuqu’ Kawoq - Maya Health Alliance, Chimaltenango, Guatemala
Bernabe-Ortiz A.:
CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru
Biggeri A.:
Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy
Burdmann E.:
Sao Paulo University, Brazil
Caplin B.:
Centre for Kidney and Bladder Health, University College London, London, United Kingdom
University College London
Catelan D.:
University of Padua, Italy
Cooper P.J.:
Institute of Infection and Immunity, St George's University of London, London, United Kingdom
School of Medicine, Universidad Internacional del Ecuador, Quito, Ecuador
Cortés S.:
Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontifical Catholic University of Chile, Santiago, Chile
Crampin A.C.:
Malawi Epidemiology and Intervention Research Unit (MEIRU), Malawi
School of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom
de Santiago M.:
Johns Hopkins Bloomberg School of Public Health, United States
Dhimal M.:
Research Section, Nepal Health Research Council, Kathmandu, Nepal
Doccioli C.:
University of Florence, Italy
Dorevitch S.:
University of Illinois Chicago, Kenya
Ferreccio C.:
Pontifical Catholic University of Chile, Chile
Glaser J.:
La Isla Network, Ada, MI, United States
Granadillo E.:
International University of Ecuador, Ecuador
Gualan M.:
International University of Ecuador, Ecuador
Gummidi B.:
George Institute, India
Gunawardena N.:
World Health Organization South-East Asia Regional Office, New Delhi, India
Hamilton S.:
Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
Hathaway M.:
Division of Environmental and Occupational Health Sciences, School of Public Health, University of Illinois Chicago, Chicago, IL, United States
Jakobsson K.:
School of Public Health and Community Medicine, University of Gothenburg, Gothenburg, Sweden
La Isla Network, Ada, MI, United States
Jarhyan P.:
Public Health Foundation of India, India
Jha V.:
George Institute for Global Health, University of New South Wales, New Delhi, India
School of Public Health, Imperial College, London, United Kingdom
Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, India
John O.:
George Institute, India
Johnson R.J.:
Colorado University, United States
Kaur P.:
Isaac Centre for Public Health, Indian Institute of Science, Bengaluru, India
Kitiyakara C.:
Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Kongtip P.:
Mahdiol University, Thailand
Kromhout H.:
Utrecht University, Netherlands
Levin A.:
University of British Columbia, Canada
Madero M.:
Ignacio Chavez Institute, Mexico
McLean E.:
London School of Hygiene and Tropical Medicine, United Kingdom
Miranda J.J.:
Universidad Peruana Cayetano Heredia, Peru
Mkandawire J.:
Malawi Epidemiology and Intervention Research Unit (MEIRU), Malawi
Mohan S.:
Centre for Chronic Conditions and Injuries, Public Health Foundation of India, New Delhi, India
Murali S.:
Indian Council of Medical Research–National Institute of Epidemiology (ICMR-NIE), India
Nair D.:
Centre for Kidney and Bladder Health, University College London, London, United Kingdom
Department of Clinical Biochemistry, Royal Free Hospital, London, United Kingdom
Health Services Laboratories, London, United Kingdom
University College London
Nakanga W.:
Malawi Epidemiology and Intervention Research Unit (MEIRU), Malawi
Nitsch D.:
Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom
Njoroge M.:
Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom
Nyirenda M.:
Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Uganda
Pearce N.:
Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom
Poudyal A.:
Research Section, Nepal Health Research Council, Kathmandu, Nepal
Prabhakaran D.:
Centre for Chronic Conditions and Injuries, Public Health Foundation of India, New Delhi, India
Prasad N.:
Sanjay Gandhi Post Graduate Institute of Medical Sciences, India
Quirós-Alcalá L.:
Johns Hopkins Bloomberg School of Public Health, United States
Remuzzi G.:
Istituto Mario Negri, Italy
Robertson S.:
Clinical Trials Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
Rohloff P.:
Center for Indigenous Health Research, Maya Health Alliance, Wuqu' Kawoq, Guatemala
Romero-Sandoval N.:
International University of Ecuador, Ecuador
Ruiz-Alejos A.:
Universidad Peruana Cayetano Heredia, Peru
Sakthivel M.:
Indian Council of Medical Research, India
Saran R.:
University of Michigan, United States
Senanayake S.:
Health Services and Systems Research, Duke-NUS (National University of Singapore) Medical School, Singapore
Duke-NUS (National University of Singapore) Medical School, Singapore
Shaw L.:
Wuqu’ Kawoq Maya Health Alliance, Guatemala
Singh A.:
Harvard Medical School, Harvard University, Boston, MA, United States
Smeeth L.:
London School of Hygiene and Tropical Medicine, United Kingdom
Sotomayor C.:
Universidad de Chile, Chile
Tuiz E.:
Wuqu’ Kawoq Maya Health Alliance, Guatemala
Venkateshmurthy N.S.:
Public Health Foundation of India, India
Venugopal V.:
Sri Ramachandra Institute of Higher Education and Research, India
Wickramasinghe S.C.:
Ministry of Health, Sri Lanka
Noncommunicable Diseases Bureau, Ministry of Health, Sri Lanka
hybrid, All Open Access; Hybrid Gold Open Access
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