The Peru Cervical Cancer Prevention Study (PERCAPS): The technology to make screening accessible
Por:
Levinson K.L., Abuelo C., Salmeron J., Chyung E., Zou J., Belinson S.E., Wang G., Santos C., Vallejos C.S., Belinson J.L.
Publicada:
1 ene 2013
Resumen:
Objective: This study utilized a combination of HPV self-sampling, iFTA elute specimen cards, and long distance transport for centralized processing of specimens to determine the feasibility of large-scale screening in remote and transient populations. Methods: This study was performed in two locations in Peru (Manchay and Iquitos). The "Just For Me" cervico-vaginal brush and iFTA elute cards were used for the collection and transport of specimens. Samples were shipped via FedEx to China and tested for 14 types of high-risk HPV using PCR based MALDI-TOF. HPV positive women were treated with cryotherapy after VIA triage, and followed-up with colposcopy, biopsy, ECC, and repeat HPV testing at 6 months. Results: Six hundred and forty three women registered, and 632 returned a sample over a 10 day period. Within 2 weeks, specimens were shipped, samples tested, and results received by study staff. Sixty-eight women (10.8%) tested positive, and these results were delivered over 4 days. Fifty-nine HPV positive women (87%) returned for evaluation and treatment, and 2 had large lesions not suitable for cryotherapy. At 6 months, 42 women (74%) returned for follow-up, and 3 had CIN 2 (all positive samples from the endocervical canal). Ninety eight percent of participants reported that they would participate in this type of program again. Conclusions: Utilizing HPV self-sampling, solid media specimen cards for long distance transport, and centralized high throughput processing, we achieved rapid delivery of results, high satisfaction levels, and low loss to follow-up for cervical cancer screening in remote and transient populations. © 2013 Elsevier Inc. All rights reserved.
Filiaciones:
Levinson K.L.:
Cleveland Clinic, Cleveland, OH 44195, 9500 Euclid Ave, United States
Abuelo C.:
National Institute of Health, Bethesda MD 20892, 31 Center Dr., United States
Salmeron J.:
Instituto Mexicano Del Seguro Social, Col. Chapultepec, Cuernavaca Morelos, Plan de Ayala y Av. Central, Mexico
Chyung E.:
Case Western Reserve School of Medicine, Cleveland, OH 44106, 2109 Adelbert Rd, United States
Zou J.:
BGI-Shenzhen, Yantian District, Shenzhen 518083, Beishan Industrial Zone, China
Belinson S.E.:
Preventive Oncology International, Cleveland, OH 44118, 2762 Fairmount Blvd, United States
Wang G.:
Preventive Oncology International, Cleveland, OH 44118, 2762 Fairmount Blvd, United States
Santos C.:
Division de Investigacion-Oncosalud, 2525, Miraflores Lima, Avenida Benavides, Peru
Vallejos C.S.:
Division de Investigacion-Oncosalud, 2525, Miraflores Lima, Avenida Benavides, Peru
Belinson J.L.:
Preventive Oncology International, Cleveland, OH 44118, 2762 Fairmount Blvd, United States
Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, 9500 Euclid Ave, United States
All Open Access; Green Open Access
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