Hepatoprotective effect of the Sechium HD-Victor hybrid extract in a model of liver damage induced by carbon tetrachloride in mice
Por:
Osorio E.-S., María-Guadalupe R.-P., Víctor-Manuel M.-N., Jorge C.-Í., Marcos S.-H., Juana R.-P., Ernesto R.-L., Benny W.-S., Graciela G.-G., Taide-Laurita A.-U., Víctor-Manuel C.-S., Itzen A.-S.
Publicada:
1 ene 2025
Resumen:
Sechium spp., is a vegetable species renowned for its pharmacological properties, including hepatoprotective activity. This species can crossbreed with its wild relatives, leading to the creation of an HD-Victor hybrid with higher levels of flavonoids, cucurbitacins, and phenolic acids compared to the Sechium edule. However, the antioxidant and hepatoprotective properties of this hybrid are not well-known. We investigated the hepatoprotective effect of HD-Victor hybrid extract on a hepatic-damage mouse model induced by carbon tetrachloride (CCl4). We conducted a phytochemical characterization and quantified its antioxidant activity. Subsequently, we evaluated the extract at different concentrations, testing the potential to mitigate liver damage induced by CCl4. After, we performed tests to assess liver function through AST, ALT, ALP and albumin, antioxidant levels, and histopathological examination. Our findings reveal that HD-Victor hybrid extract is rich in flavonoids, phenolic acids, and cucurbitacins and shows DPPH-free radical inhibition, protection in liver function, and increased antioxidant levels. Therefore, the Sechium HD-Victor hybrid extract exerts a protective effect against hepatic damage induced by oxidative stress, showing its potential as a hepatoprotective agent. © 2025 The Authors
Filiaciones:
Osorio E.-S.:
Hematopoiesis and Leukemia Laboratory, Research Unit on Cell Differentiation and Cancer, Faculty of High Studies Zaragoza, National Autonomous University of Mexico, Mexico City, CP 09230, Mexico
María-Guadalupe R.-P.:
Hematopoiesis and Leukemia Laboratory, Research Unit on Cell Differentiation and Cancer, Faculty of High Studies Zaragoza, National Autonomous University of Mexico, Mexico City, CP 09230, Mexico
Víctor-Manuel M.-N.:
Research Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, Mexico City, 09230, Mexico
Jorge C.-Í.:
Innovation in Natural Resource Management, Postgraduate College, Campus San Luis Potosí, Salinas de Hidalgo, San Luis Potosí, CP 78622, Mexico
Marcos S.-H.:
Botany Department, Postgraduate College, Campus Montecillo, km 36.5 Carretera México-Texcoco, Texcoco, 56230, Mexico
Juana R.-P.:
Research Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, Mexico City, 09230, Mexico
Ernesto R.-L.:
Hematopoiesis and Leukemia Laboratory, Research Unit on Cell Differentiation and Cancer, Faculty of High Studies Zaragoza, National Autonomous University of Mexico, Mexico City, CP 09230, Mexico
Benny W.-S.:
Hematopoiesis and Leukemia Laboratory, Research Unit on Cell Differentiation and Cancer, Faculty of High Studies Zaragoza, National Autonomous University of Mexico, Mexico City, CP 09230, Mexico
Graciela G.-G.:
Research Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, Mexico City, 09230, Mexico
Taide-Laurita A.-U.:
Research Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, Mexico City, 09230, Mexico
Víctor-Manuel C.-S.:
Universidad Autónoma Chapingo, Centro Regional Universitario Oriente, Veracruz, 94100, Mexico
Itzen A.-S.:
Hematopoiesis and Leukemia Laboratory, Research Unit on Cell Differentiation and Cancer, Faculty of High Studies Zaragoza, National Autonomous University of Mexico, Mexico City, CP 09230, Mexico
Department of Biomedical Sciences, School of Medicine, Faculty of High Studies Zaragoza, National Autonomous University of Mexico, Mexico City, CP 56410, Mexico
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