Non-Categorical Analyses Identify Rotenone-Induced 'Parkinsonian' Rats Benefiting from Nano-Emulsified Punicic Acid (Nano-PSO) in a Phenotypically Diverse Population: Implications for Translational Neurodegenerative Therapies
Por:
Sánchez-Camacho, JV, Gómez-Chavarín, M, Galindo-Solano, N, Padilla-Cortés, P, Maldonado-García, JL, Pérez-Sánchez, G, Pavón, L, Ramírez-Santos, J, Roldán, GR, Gómez-López, M, Gutierrez-Ospina, G
Publicada:
1 dic 2024
Resumen:
The pursuit of nutraceuticals to improve the quality of life for patients with neurodegenerative conditions is a dynamic field within neuropharmacology. Unfortunately, many nutraceuticals that show promise in preclinical studies fail to demonstrate significant clinical benefits in human trials, leading to their exclusion as therapeutic options. This discrepancy may stem from the categorical interpretation of preclinical and clinical results. Basic researchers often assume that non-human experimental animals exhibit less phenotypic variability than humans. This belief overlooks interindividual phenotype variation, thereby leading to categorical conclusions being drawn from experiments. Consequently, when human clinical trials are conducted, the researchers expect similarly conclusive results. If these results are not achieved, the nutraceutical is deemed ineffective for clinical use, even if numerous individuals might benefit. In our study, we evaluated whether analyzing phenotype variability and similarity through non-categorical methods could help identify rotenone (ROT)-treated rats that might benefit from consuming nano-emulsified punicic acid (Nano-PSO), even if the prevention of "parkinsonism" or the restoration of neurometabolic function is inconsistent across individuals. Our findings supported this hypothesis. The benefits of Nano-PSO were not categorical; however, analyzing phenotype variance allowed us to identify ROT rats with varying degrees of benefit from Nano-PSO consumption. Hence, the translational potential of results from basic science studies testing nutraceuticals as pharmaceutical products against neurodegeneration may improve if researchers also interpret their results using non-categorical methods of data analysis for population screening, even if the overall therapeutic outcomes for the entire population show internal inconsistencies.
Filiaciones:
Sánchez-Camacho, JV:
Inst Politecn Nacl, Escuela Super Med, Secc Estudios Posgrad, Ciudad De Mexico 11340, Mexico
Gómez-Chavarín, M:
Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Lab Med Regenerat & Canales Ion, Ciudad De Mexico 04510, Mexico
Galindo-Solano, N:
Univ Nacl Autonoma Mexico, Dept Biol Celular & Fisiol, Lab Biol Sistemas, Inst Invest Biomed, Ciudad De Mexico 04510, Mexico
Univ Nacl Autonoma Mexico, Unidad Posgrad, Programa Doctorado Ciencias Biomed, Ciudad De Mexico 04510, Mexico
Padilla-Cortés, P:
Univ Nacl Autonoma Mexico, Unidad Cromatog, Inst Invest Biomed, Ciudad De Mexico 04510, Mexico
Maldonado-García, JL:
Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Ciudad De Mexico 04510, Mexico
Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Inmunol, Ciudad De Mexico 11340, Mexico
Pérez-Sánchez, G:
Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Lab Psicoinmunol, Direcc Invest Neurociencias, Ciudad De Mexico 14370, Mexico
Pavón, L:
Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Lab Psicoinmunol, Direcc Invest Neurociencias, Ciudad De Mexico 14370, Mexico
Ramírez-Santos, J:
Univ Nacl Autonoma Mexico, Dept Biol Celular & Fisiol, Lab Biol Sistemas, Inst Invest Biomed, Ciudad De Mexico 04510, Mexico
Roldán, GR:
Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Lab Neurol Conductual, Ciudad De Mexico 04510, Mexico
Gómez-López, M:
Inst Politecn Nacl, Escuela Super Med, Secc Estudios Posgrad, Ciudad De Mexico 11340, Mexico
Gutierrez-Ospina, G:
Univ Nacl Autonoma Mexico, Dept Biol Celular & Fisiol, Lab Biol Sistemas, Inst Invest Biomed, Ciudad De Mexico 04510, Mexico
Univ Nacl Autonoma Mexico, Fac Psicol, Coordinac Psicobiol & Neurociencias, Ciudad De Mexico 04510, Mexico
gold, All Open Access; Gold Open Access
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