Synergistic Assembly of 1DZnO and Anti-CYFRA 21-1: A Physicochemical Approach to Optical Biosensing
Por:
Salinas R.A., Martínez Tolibia S.E., Zayas-Bazán P.G., Rodil S.E., Mathew M.T., Navarrete A., Santana G., Dutt A.
Publicada:
1 ene 2024
Resumen:
Objective: We conducted a comprehensive physicochemical analysis of one-dimensional ZnO nanowires (1DZnO), incorporating anti-CYFRA 21-1 immobilization to promote fast optical biomarker detection up to 10 ng ml-1. Impact Statement: This study highlights the effectiveness of proof-of-concept 1DZnO nanoplatforms for rapid cancer biomarker detection by examining the nanoscale integration of 1DZnO with these bioreceptors to deliver reliable photoluminescent output signals. Introduction: The urgent need for swift and accurate prognoses in healthcare settings drives the rise of sensitive biosensing nanoplatforms for cancer detection, which has benefited from biomarker identification. CYFRA 21-1 is a reliable target for the early prediction of cancer formation that can be perceptible in blood, saliva, and serum. However, 1DZnO nanostructures have been barely applied for CYFRA 21-1 detection. Methods: We assessed the nanoscale interaction between 1DZnO and anti-CYFRA 21-1 antibodies to develop rapid CYFRA 21-1 detection in two distinct matrices: PhosphateBuffered Saline (PBS) buffer and artificial saliva. The chemical modifications were tracked utilizing Fourier transform infrared spectroscopy, while transmission electron microscopy and energy dispersive spectroscopy confirmed antigen–antibody interplay over nanostructures. Results: Our results show high antibody immobilization efficiencies, affirming the effectiveness of 1DZnO nanoplatforms for rapid CYFRA 21-1 testing within a 5-min detection window in both PBS and artificial saliva. Photoluminescence measurements also revealed distinct optical responses across biomarker concentrations ranging from 10 to 1,000 ng ml-1. Conclusion: Discernible PL signal responses obtained after 5 min affirm the potential of 1DZnO nanoplatforms for further advancement in optical biomarker detection for application in early cancer prognosis. © 2024 Rafael A. Salinas et al.
Filiaciones:
Salinas R.A.:
Departamento de Materiales de Baja Dimensionalidad, Instituto de Investigaciones, Materiales Universidad Nacional Autónoma de México, Mexico City, C.P. 04510, Mexico
Martínez Tolibia S.E.:
Departamento de Materiales de Baja Dimensionalidad, Instituto de Investigaciones, Materiales Universidad Nacional Autónoma de México, Mexico City, C.P. 04510, Mexico
Zayas-Bazán P.G.:
Departamento de Materiales de Baja Dimensionalidad, Instituto de Investigaciones, Materiales Universidad Nacional Autónoma de México, Mexico City, C.P. 04510, Mexico
Rodil S.E.:
Departamento de Materiales de Baja Dimensionalidad, Instituto de Investigaciones, Materiales Universidad Nacional Autónoma de México, Mexico City, C.P. 04510, Mexico
Mathew M.T.:
Department of Biomedical Science, UIC College of Medicine, Rockford, 61107, IL, United States
Navarrete A.:
Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Mexico City, C.P. 04510, Mexico
Santana G.:
Departamento de Materiales de Baja Dimensionalidad, Instituto de Investigaciones, Materiales Universidad Nacional Autónoma de México, Mexico City, C.P. 04510, Mexico
Dutt A.:
Departamento de Materiales de Baja Dimensionalidad, Instituto de Investigaciones, Materiales Universidad Nacional Autónoma de México, Mexico City, C.P. 04510, Mexico
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