Effect of Mucuna pruriens seed extract on depression-like behavior derived from mild traumatic brain injury in rats
Por:
Mata-Bermudez, A, Trejo-Chávez, R, Martínez-Vargas, M, Pérez-Arredondo, A, Martínez-Cardenas, MD, Diaz-Ruiz, A, Rios, C, Romero-Sánchez, HA, Martínez-Antonio, A, Navarro, L
Publicada:
1 ene 2024
Resumen:
Background: : Traumatic brain injury (TBI) is a severe health problem for which there is no specific fi c treatment, leading to neurological or neuropsychological consequences. One of the most described disorders, even after mild TBI (mTBI), is depression, related to mechanisms involving reactive oxygen species (ROS). The Mucuna pruriens (M. pruriens) plant has various antioxidant, neuroprotective, and anti-inflammatory fl ammatory properties. Purpose: : There is insufficient fi cient evidence of M. pruriens use for the treatment of neurobehavioral and depressive impairments induced by TBI and of the mechanisms underlying this effect, so we aimed to evaluate the ability of shortterm administration of M. pruriens extract to prevent neurobehavioral impairment and depression-like behaviors in a murine model of mTBI as well as evaluate the role of oxidative stress. Methods: : Male Wistar rats underwent mTBI or sham surgery. Immediately after, they were treated with vehicle or M. pruriens extract (50 mg/kg ip/day for fi ve days). We evaluated neurobehavioral recovery using the Neurobehavioral Severity Scale-Revised (NSS-R) and the immobility time in the forced swimming test 3, 7, 15, 30, and 60 days after mTBI. In addition, lipid peroxidation (LP) and GSH concentrations were determined in some brain areas (motor cortex, striatum, midbrain, and nucleus accumbens). Results: : M. pruriens extract did not decrease neurobehavioral impairment caused by mTBI. Nevertheless, it prevented depression-like behaviors starting three days after mTBI, reduced LP, and increased GSH in some brain areas. Conclusions: : M. pruriens may prevent depression-like behaviors and reduce oxidative stress by decreasing LP and increasing concentrations of antioxidant compounds.
Filiaciones:
Mata-Bermudez, A:
Univ Nacl Autonoma Mexico, Dept Fisiol, Apdo Postal 70-250, Ciudad De Mexico 04510, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Apdo Postal 70-250, Ciudad De Mexico 04510, Mexico
Trejo-Chávez, R:
Univ Nacl Autonoma Mexico, Dept Fisiol, Apdo Postal 70-250, Ciudad De Mexico 04510, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Apdo Postal 70-250, Ciudad De Mexico 04510, Mexico
Univ Nacl Autonoma Mexico, Doctorado Ciencias Biomed, Apdo Postal 70-250, Ciudad De Mexico 04510, Mexico
Martínez-Vargas, M:
Univ Nacl Autonoma Mexico, Dept Fisiol, Apdo Postal 70-250, Ciudad De Mexico 04510, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Apdo Postal 70-250, Ciudad De Mexico 04510, Mexico
Pérez-Arredondo, A:
Univ Nacl Autonoma Mexico, Dept Fisiol, Apdo Postal 70-250, Ciudad De Mexico 04510, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Apdo Postal 70-250, Ciudad De Mexico 04510, Mexico
Martínez-Cardenas, MD:
Univ Autonoma Metropolitana, Dept Atenc Salud, Unidad Xochimilco, Ciudad De Mexico, Mexico
Diaz-Ruiz, A:
Inst Nacl Neurol & Neurocirug Manuel Velasco Suare, Dept Neuroquim, Ciudad De Mexico, Mexico
Rios, C:
Univ Autonoma Metropolitana, Dept Sistemas Biol, Unidad Xochimilco, Lab Neurofarmacol Mol, Ciudad De Mexico, Mexico
Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Direcc Invest, Ciudad De Mexico, Mexico
Romero-Sánchez, HA:
Univ Autonoma Metropolitana, Dept Atenc Salud, Unidad Xochimilco, Ciudad De Mexico, Mexico
Martínez-Antonio, A:
Natl Polytech Inst Cinvestav, Ctr Res & Adv Studies, Genet Engn Dept, Biol Engn Lab, Campus Irapuato, Guanajuato, Mexico
Navarro, L:
Univ Nacl Autonoma Mexico, Dept Fisiol, Apdo Postal 70-250, Ciudad De Mexico 04510, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Apdo Postal 70-250, Ciudad De Mexico 04510, Mexico
gold, All Open Access; Gold Open Access
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