Casiopeina III-ia: A Copper Compound with Potential Use for Treatment of Infections Caused by Leishmania mexicana
Por:
Delgado-Domínguez, J, Mejía-Camacho, L, Torres-Martínez, L, Zamora-Chimal, J, Cervantes-Sarabia, R, Espinoza-Guillen, A, Ruiz-Azuara, L, Becker, I
Publicada:
18 mar 2024
Ahead of Print:
1 mar 2024
Resumen:
Introduction: Casiopeina III-ia (CasIII-ia) is a mixed chelate copper (II) compound capable of interacting with free radicals generated in the respiratory chain through redox reactions, producing toxic reactive oxygen species (ROS) that compromise the viability of cancer cells, bacteria and protozoa. Due to its remarkable effect on protozoa, this study evaluated the effect of CasIII-ia on Leishmania mexicana amastigotes and its potential use as a treatment for cutaneous leishmaniasis in the murine model. Methods: We analyzed the leishmanicidal effect of CasIII-ia on L. mexicana amastigotes and on their survival in bone marrow-derived macrophages. Furthermore, we evaluated the production of ROS in treated parasites and the efficacy of CasIII-ia in the treatment of mice infected with L. mexicana. Results: Our results show that CasIII-ia reduces parasite viability in a dose-dependent manner that correlates with increased ROS production. A decrease in the size of footpad lesions and in parasite loads was observed in infected mice treated with the intraperitoneal administration of CasIII-ia. Conclusions: We propose CasIII-ia as a potential drug for the treatment of cutaneous leishmaniasis.
Filiaciones:
Delgado-Domínguez, J:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Mexico City, Mexico
Mejía-Camacho, L:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Mexico City, Mexico
Torres-Martínez, L:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Mexico City, Mexico
Zamora-Chimal, J:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Mexico City, Mexico
Cervantes-Sarabia, R:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Mexico City, Mexico
Espinoza-Guillen, A:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Quim Inorgan & Nucl, Mexico City, Mexico
Ruiz-Azuara, L:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Quim Inorgan & Nucl, Mexico City, Mexico
Becker, I:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Mexico City, Mexico
hybrid, All Open Access; Hybrid Gold Open Access
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