Influence of adiposity and sex on SARS-CoV-2 antibody response in vaccinated university students: A cross-sectional ESFUERSO study
Por:
Perales-Torres A.L., Perez-Navarro L.M., Garcia-Oropesa E.M., Diaz-Badillo A., Martinez-Lopez Y.E., Rosas M., Castillo O., Ramirez-Quintanilla L., Cervantes J., Sciutto E., Munguia Cisneros C.X., Ramirez-Pfeiffer C., Vela L., Tapia B., Lopez-Alvarenga J.C.
Publicada:
1 ene 2024
Resumen:
Prior studies have identified various determinants of differential immune responses to COVID-19. This study focused on the Ig-G anti-RBD marker, analyzing its potential correlations with sex, vaccine type, body fat percentage, metabolic risk, perceived stress, and previous COVID-19 exposure. In this study, data (available in S1 Data) were obtained from 108 participants from the ESFUERSO cohort, who completed questionnaires detailing their COVID-19 experiences and stress levels assessed through the SISCO scale. IgG anti-RBD concentrations were quantified using an ELISA assay developed by UNAM. Multiple regression analysis was employed to control for covariates, including sex, age, body fat percentage, body mass index (BMI), and perceived stress. This sample comprised young individuals (average age of 21.4 years), primarily consisting of females (70%), with a substantial proportion reporting a family history of diabetes, hypertension, or obesity. Most students had received the Moderna or Pfizer vaccines, and 91% displayed a positive anti-RBD response. A noteworthy finding was the interaction between body fat percentage and sex. In males, increased adiposity was associated with decreased Ig-G anti-RBD concentration; in females, the response increased. Importantly, this pattern remained consistent regardless of the vaccine received. No significant associations were observed for dietary habits or perceived stress variables. This research reports the impact of sex and body fat percentage on the immune response through Ig-G anti-RBD levels to COVID-19 vaccines. The implications of these findings offer a foundation for educational initiatives and the formulation of preventive policies aimed at mitigating health disparities. © 2024 Perales-Torres et al.
Filiaciones:
Perales-Torres A.L.:
Unidad Académica Multidisciplinaria Reynosa Aztlan, Universidad Autónoma de Tamaulipas, Tamaulipas, Reynosa, Mexico
Perez-Navarro L.M.:
Departamento de Nefrología, Hospital General de México Dr. Eduardo Liceaga, Mexico City, Mexico
Garcia-Oropesa E.M.:
Unidad Académica Multidisciplinaria Reynosa Aztlan, Universidad Autónoma de Tamaulipas, Tamaulipas, Reynosa, Mexico
Diaz-Badillo A.:
Public Health Research Group, Department of Life Sciences, Texas A&M University-San Antonio, San Antonio, TX, United States
Escuela de Medicina, Universidad México Americana del Norte, Tamaulipas, Reynosa, Mexico
Martinez-Lopez Y.E.:
School of Public Health, University of Texas Health Science Center at Houston, Brownsville, TX, United States
Rosas M.:
Unidad Académica Multidisciplinaria Reynosa Aztlan, Universidad Autónoma de Tamaulipas, Tamaulipas, Reynosa, Mexico
Castillo O.:
Unidad Académica Multidisciplinaria Reynosa Aztlan, Universidad Autónoma de Tamaulipas, Tamaulipas, Reynosa, Mexico
Ramirez-Quintanilla L.:
Unidad Académica Multidisciplinaria Reynosa Aztlan, Universidad Autónoma de Tamaulipas, Tamaulipas, Reynosa, Mexico
Cervantes J.:
Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
Sciutto E.:
Instituto de Investigaciones Biomedicas, Universidad Nacional Autónoma de Mexico, Mexico City, Mexico
Munguia Cisneros C.X.:
Centro Especializado de Diabetes y Metabolismo CEDIAMET, Universidad Mexico Americana del Norte, Tamaulipas, Reynosa, Mexico
Ramirez-Pfeiffer C.:
Unidad Académica Multidisciplinaria Reynosa Aztlan, Universidad Autónoma de Tamaulipas, Tamaulipas, Reynosa, Mexico
Escuela de Medicina, Universidad México Americana del Norte, Tamaulipas, Reynosa, Mexico
Vela L.:
School of Medicine, University of Texas Rio Grande Valley, UTRGV, Edinburg, TX, United States
Tapia B.:
School of Medicine, University of Texas Rio Grande Valley, UTRGV, Edinburg, TX, United States
Lopez-Alvarenga J.C.:
Escuela de Medicina, Universidad México Americana del Norte, Tamaulipas, Reynosa, Mexico
School of Medicine, University of Texas Rio Grande Valley, UTRGV, Edinburg, TX, United States
gold, Green Published
|