Exploring the relationship between admixture and genetic susceptibility to attention deficit hyperactivity disorder in two Latin American cohorts
Por:
Garzón Rodríguez N., Briceño-Balcázar I., Nicolini H., Martínez-Magaña J.J., Genis-Mendoza A.D., Flores-Lázaro J.C., Villatoro Velázquez J.A., Bustos Gamiño M., Medina-Mora M.E., Quiroz-Padilla M.F.
Publicada:
1 ene 2024
Resumen:
Contemporary research on the genomics of Attention Deficit Hyperactivity Disorder (ADHD) often underrepresents admixed populations of diverse genomic ancestries, such as Latin Americans. This study explores the relationship between admixture and genetic associations for ADHD in Colombian and Mexican cohorts. Some 546 participants in two groups, ADHD and Control, were genotyped with Infinium PsychArray®. Global ancestry levels were estimated using overall admixture proportions and principal component analysis, while local ancestry was determined using a method to estimate ancestral components along the genome. Genome-wide association analysis (GWAS) was conducted to identify significant associations. Differences between Colombia and Mexico were evaluated using appropriate statistical tests. 354 Single-nucleotide polymorphisms (SNPs) and Single-nucleotide variants (SNVs) related to some genes and intergenic regions exhibited suggestive significance (p-value < 5*10e-5) in the GWAS. None of the variants revealed genome-wide significance (p-value < 5*10e-8). The study identified a significant relationship between risk SNPs and the European component of admixture, notably observed in the LOC105379109 gene. Despite differences in risk association loci, such as FOXP2, our findings suggest a possible homogeneity in genetic variation’s impact on ADHD between Colombian and Mexican populations. Current reference datasets for ADHD predominantly consist of samples with high European ancestry, underscoring the need for further research to enhance the representation of reference populations and improve the identification of ADHD risk traits in Latin Americans. © The Author(s) 2024.
Filiaciones:
Garzón Rodríguez N.:
Laboratorio de Bases Biológicas del Comportamiento, Facultad de Psicología, Universidad de La Sabana, Chía, Colombia
Doctorado en Biociencias, Facultad de Ingeniería, Universidad de La Sabana, Chía, Colombia
Briceño-Balcázar I.:
Laboratorio de Genética, Facultad de Medicina, Universidad de La Sabana, Chía, Colombia
Nicolini H.:
Laboratorio de Enfermedades Psiquiátricas, Neurodegenerativas y Adicciones, Instituto Nacional de Medicina Genómica, Secretaría de Salud, Mexico City, Mexico
Martínez-Magaña J.J.:
Laboratorio de Enfermedades Psiquiátricas, Neurodegenerativas y Adicciones, Instituto Nacional de Medicina Genómica, Secretaría de Salud, Mexico City, Mexico
Genis-Mendoza A.D.:
Laboratorio de Enfermedades Psiquiátricas, Neurodegenerativas y Adicciones, Instituto Nacional de Medicina Genómica, Secretaría de Salud, Mexico City, Mexico
Hospital Psiquiátrico Infantil Dr Juan N. Navarro, Mexico City, Mexico
Flores-Lázaro J.C.:
Facultad de Psicología, Universidad Nacional Autónoma de México - UNAM, Mexico City, Mexico
Villatoro Velázquez J.A.:
Instituto Nacional de Psiquiatría Ramon de la Fuente Muñiz, Secretaría de Salud, Mexico City, Mexico
Bustos Gamiño M.:
Instituto Nacional de Psiquiatría Ramon de la Fuente Muñiz, Secretaría de Salud, Mexico City, Mexico
Medina-Mora M.E.:
Facultad de Psicología, Universidad Nacional Autónoma de México - UNAM, Mexico City, Mexico
Instituto Nacional de Psiquiatría Ramon de la Fuente Muñiz, Secretaría de Salud, Mexico City, Mexico
Quiroz-Padilla M.F.:
Laboratorio de Bases Biológicas del Comportamiento, Facultad de Psicología, Universidad de La Sabana, Chía, Colombia
All Open Access; Hybrid Gold Open Access
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