Inflammatory profile in patients with rheumatoid arthritis and sarcopenia
Por:
Lozada-Mellado M., Llorente L., Hinojosa-Azaola A., Ogata-Medel M., Valdez-Echeverría R.D., Lira-Reyes A.R., Castillo-Martínez L.
Publicada:
1 ene 2024
Ahead of Print:
1 abr 2024
Resumen:
Introduction: Sarcopenia is characterized by the loss of muscle mass and strength associated with aging; however, individuals with chronic diseases are at risk at the early stages. In rheumatoid arthritis (RA), sustained chronic inflammation influences muscle deterioration. It may expedite the development of sarcopenia, which has been linked to physical disability, cardiovascular events, disease activity of RA, and premature death. We aimed to compare the inflammatory profiles of patients with RA with and without sarcopenia. Methods: This cross-sectional study involved 165 women with RA. Sarcopenia was diagnosed according to criteria established by the European Working Group on Sarcopenia in Older People. To assess the inflammatory profile, concentrations of cytokines such as EGF, IL-17, IL-1a, IL-1ß, IL-6, TNFa, TNFß, and creatine kinase (CK) were measured. Results: The prevalence of sarcopenia was 15.8% (95% CI: 8.9–18.2). The median age of patients with sarcopenia was 59.5 years (49.8—65.3), compared to 50 years (43—59 years) p = 0.001. The disease duration was also longer in patients with sarcopenia, 21 years (15—30), compared to those without sarcopenia, 13 years (7.3—20) p = 0.001. The inflammatory profile differed between patients with and without sarcopenia, revealing that the cytokines IL-1a, IL-6, and TNFß concentrations were significantly higher (p < 0.05) in patients with sarcopenia, adjusted for BMI, age, and disease duration. Conclusion: Patients with RA and sarcopenia were older and exhibited longer disease duration and higher levels of inflammatory cytokines compared to those without sarcopenia. These findings suggest potential implications for clinical outcomes. (Table presented.). © The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR) 2024.
Filiaciones:
Lozada-Mellado M.:
Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Mexico City, Mexico
Llorente L.:
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Hinojosa-Azaola A.:
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Ogata-Medel M.:
Clinical Nutrition Service, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Mexico City, 14080, Mexico
Valdez-Echeverría R.D.:
Deparment of Central Laboratory, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Lira-Reyes A.R.:
Deparment of Central Laboratory, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Castillo-Martínez L.:
Clinical Nutrition Service, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Mexico City, 14080, Mexico
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