Actinomycetota bioprospecting from ore-forming environments
Por:
Aguilar C., Alwali A., Mair M., Rodriguez-Orduña L., Contreras-Peruyero H., Modi R., Roberts C., Sélem-Mojica N., Licona-Cassani C., Parkinson E.I.
Publicada:
1 ene 2024
Resumen:
Natural products from Actinomycetota have served as inspiration for many clinically relevant therapeutics. Despite early triumphs in natural product discovery, the rate of unearthing new compounds has decreased, necessitating inventive approaches. One promising strategy is to explore environments where survival is challenging. These harsh environments are hypothesized to lead to bacteria developing chemical adaptations (e.g. natural products) to enable their survival. This investigation focuses on ore-forming environments, particularly fluoride mines, which typically have extreme pH, salinity and nutrient scarcity. Herein, we have utilized metagenomics, metabolomics and evolutionary genome mining to dissect the biodiversity and metabolism in these harsh environments. This work has unveiled the promising biosynthetic potential of these bacteria and has demonstrated their ability to produce bioactive secondary metabolites. This research constitutes a pioneering endeavour in bioprospection within fluoride mining regions, providing insights into uncharted microbial ecosystems and their previously unexplored natural products.
Filiaciones:
Aguilar C.:
Department of Chemistry, Purdue University, West Lafayette, 47907, IN, United States
Alwali A.:
Department of Chemistry, Purdue University, West Lafayette, 47907, IN, United States
Mair M.:
Department of Chemistry, Purdue University, West Lafayette, 47907, IN, United States
Rodriguez-Orduña L.:
Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Monterrey, Mexico
Contreras-Peruyero H.:
Centro de Ciencias Matematicas, UNAM, Morelia, Michoacán, Mexico
Modi R.:
Department of Chemistry, Purdue University, West Lafayette, 47907, IN, United States
Roberts C.:
Department of Chemistry, Purdue University, West Lafayette, 47907, IN, United States
Sélem-Mojica N.:
Centro de Ciencias Matematicas, UNAM, Morelia, Michoacán, Mexico
Licona-Cassani C.:
Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Monterrey, Mexico
Parkinson E.I.:
Department of Chemistry, Purdue University, West Lafayette, 47907, IN, United States
Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, 47907, IN, United States
gold, All Open Access; Gold Open Access
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