Epidemiology of childhood acute leukemias in marginalized populations of the central-south region of Mexico: results from a population-based registry
Por:
Flores-Lujano, J, Allende-López, A, Duarte-Rodríguez, DA, Alarcón-Ruiz, E, López-Carrillo, L, Shamah-Levy, T, Cebrián, ME, Baños-Lara, MD, Casique-Aguirre, D, Elizarrarás-Rivas, J, López-Aquino, JA, Garrido-Hernández, MA, Olvera-Caraza, D, Terán-Cerqueda, V, Martínez-José, KB, Aristil-Chery, PM, Alvarez-Rodríguez, E, Herrera-Olivares, W, Ruíz-Arguelles, GJ, Chavez-Aguilar, LA, Márquez-Toledo, A, Cano-Cuapio, LS, Luna-Silva, NC, Martínez-Martell, MA, Ramirez-Ramirez, AB, Merino-Pasaye, LE, Galván-Díaz, CA, Medina-Sanson, A, Gutiérrez-Rivera, MD, Martín-Trejo, JA, Rodriguez-Cedeño, E, Bekker-Méndez, VC, Romero-Tlalolini, MD, Cruz-Maza, A, Juarez-Avendaño, G, Pérez-Tapia, SM, Rodríguez-Espinosa, JC, Suárez-Aguirre, MC, Herrera-Quezada, F, Hernández-Díaz, A, Galván-González, LA, Mata-Rocha, M, Olivares-Sosa, AI, Rosas-Vargas, H, Jimenez-Morales, S, Cárdenas-González, M, Roces, MEAB, Duque-Molina, C, Pelayo, R, Mejia-Aranguré, JM, Nunez-Enriquez, JC
Publicada:
20 feb 2024
Resumen:
Introduction Acute leukemias (AL) are the main types of cancer in children worldwide. In Mexico, they represent one of the main causes of death in children under 20 years of age. Most of the studies on the incidence of AL in Mexico have been developed in the urban context of Greater Mexico City and no previous studies have been conducted in the central-south of the country through a population-based study. The aim of the present work was to identify the general and specific incidence rates of pediatric AL in three states of the south-central region of Mexico considered as some of the marginalized populations of Mexico (Puebla, Tlaxcala, and Oaxaca).Methods A population-based study was conducted. Children aged less than 20 years, resident in these states, and newly diagnosed with AL in public/private hospitals during the period 2021-2022 were identified. Crude incidence rates (cIR), standardized incidence rates (ASIRw), and incidence rates by state subregions (ASIRsr) were calculated. Rates were calculated using the direct and indirect method and reported per million children under 20 years of age. In addition, specific rates were calculated by age group, sex, leukemia subtype, and immunophenotype.Results A total of 388 cases with AL were registered. In the three states, the ASIRw for AL was 51.5 cases per million (0-14 years); in Puebla, it was 53.2, Tlaxcala 54.7, and Oaxaca de 47.7. In the age group between 0-19 years, the ASIRw were 44.3, 46.4, 48.2, and 49.6, in Puebla, Tlaxcala, and Oaxaca, respectively. B-cell acute lymphoblastic leukemia was the most common subtype across the three states.Conclusion The incidence of childhood AL in the central-south region of Mexico is within the range of rates reported in other populations of Latin American origin. Two incidence peaks were identified for lymphoblastic and myeloid leukemias. In addition, differences in the incidence of the disease were observed among state subregions which could be attributed to social factors linked to the ethnic origin of the inhabitants. Nonetheless, this hypothesis requires further investigation.
Filiaciones:
Flores-Lujano, J:
Hosp Pediat Dr Silvestre Frenk Freund, Ctr Med Nacl Siglo 21, Unidad Invest Med Epidemiol Clin, Inst Mexicano Seguro Social IMSS,Unidad Med Alta E, Mexico City, Mexico
Allende-López, A:
Hosp Pediat Dr Silvestre Frenk Freund, Ctr Med Nacl Siglo 21, Unidad Invest Med Epidemiol Clin, Inst Mexicano Seguro Social IMSS,Unidad Med Alta E, Mexico City, Mexico
Duarte-Rodríguez, DA:
Inst Mexicano Seguro Social IMSS, Div Desarrollo Invest Coordinac Invest Salud, Mexico City, Mexico
Alarcón-Ruiz, E:
Tecnol Nacl Mexico, Div Estudios Posgrad & Invest, Inst Tecnol Ciudad Madero, Ciudad Madero, Tamaulipas, Mexico
López-Carrillo, L:
Inst Nacl Salud Publ INSP, Ctr Invest Salud Poblac, Cuernavaca, Morelos, Mexico
Shamah-Levy, T:
Inst Nacl Salud Publ INSP, Ctr Invest Evaluac & Encuestas, Cuernavaca, Morelos, Mexico
Cebrián, ME:
Inst Politecn Nacl Cinvestav I, Ctr Invest & Estudios Avanzados CINVESTAV, Dept Toxicol, Mexico City 07360, Mexico
Baños-Lara, MD:
Univ Popular Autonoma Estado Puebla, Fac Med, Puebla, Mexico
Univ Popular Autonoma Estado Puebla, Ctr Invest Oncol Nueva Esperanza, Puebla, Mexico
Casique-Aguirre, D:
Inst Mexicano Seguro Social, Lab Cit Canc Infantil, Ctr Invest Biomed Oriente, Puebla, Mexico
Consejo Nacl Human Ciencias & Tecnol CONAHCYT, Mexico City, Mexico
Elizarrarás-Rivas, J:
Inst Mexicano Seguro Social, Coordinac Invest Salud, Oaxaca, Mexico
López-Aquino, JA:
Inst Mexicano Seguro Social, Coordinac Clin Educ Invest Salud UMF 1, Oaxaca, Mexico
Garrido-Hernández, MA:
Hosp Nino Poblano, Serv Neurocirugia Pediat, Puebla, Mexico
Olvera-Caraza, D:
Hosp Nino Poblano, Serv Neurocirugia Pediat, Puebla, Mexico
Terán-Cerqueda, V:
Inst Mexicano Seguro IMSS, Serv Oncohematol Pediat, Ctr Med Nacl CMN, Unidad Med Alta Especial UMAE,Hosp Especial Dr Man, Puebla, Mexico
Martínez-José, KB:
Inst Mexicano Seguro Social IMSS, Unidad Med Alta Especial UMAE, Ctr Med Nacl CMN, Serv Hematol,Hosp Especialidades Dr Manue Avila Ca, Pubela, Mexico
Aristil-Chery, PM:
Inst Segur & Serv Sociales Trabajadores Serv Poder, Dept Ensenanza Invest, Puebla, Mexico
Alvarez-Rodríguez, E:
Inst Segur & Serv Sociales Trabajadores Serv Poder, Serv Oncohematol Pediat, Puebla, Mexico
Inst Segur & Serv Sociales Trabajadores Estado ISS, Serv Hematol Pediat, Puebla, Mexico
Herrera-Olivares, W:
Hosp Gen Dr Eduardo Vazquez Navarro, Serv Oncohematol, Secretaria Salud SS, Puebla, Mexico
Ruíz-Arguelles, GJ:
Clin Ruiz, Ctr Hematol & Med Interna, Puebla, Mexico
Chavez-Aguilar, LA:
Inst Segur & Serv Sociales Trabajadores Estado ISS, Serv Hematol Pediat, Puebla, Mexico
Márquez-Toledo, A:
Hosp Univ Puebla BUAP, Dept Pediat, Puebla, Mexico
Cano-Cuapio, LS:
Hosp Infantil Tlaxcala, Serv Oncol Pediat, Secretaria Salud SS, Tlaxcala, Mexico
Luna-Silva, NC:
Hosp Infantil Teleton Oncol, Subdirecc Diagnost & Banco Sangre, Queretaro, Mexico
Martínez-Martell, MA:
Hosp Infantil Teleton Oncol, Subdirecc Diagnost & Banco Sangre, Queretaro, Mexico
Ramirez-Ramirez, AB:
Inst Mexicano Seguro Social IMSS, Serv Oncocrean, Hosp Gen Zona Dr Demetrio Mayoral Pardo 01, Oaxaca, Mexico
Merino-Pasaye, LE:
Inst Segur & Serv Sociales Trabajadores Estado ISS, Ctr Med Nacl 20 Noviembre, Serv Hematol Pediat, Mexico City, Mexico
Galván-Díaz, CA:
Inst Nacl Pediat, Dept Neurocirugia, Secretaria Salud, Mexico City 04530, Mexico
Medina-Sanson, A:
Hosp Infantil Mexico Dr Federico Gomez, Dept Hemato Oncol, Mexico City, Mexico
Gutiérrez-Rivera, MD:
Inst Mexicano Seguro Social IMSS, Unidad Med Alta Especial UMAE, Ctr Med Nacl CMN Siglo 21, Serv Hematol,Hosp Pediat Dr Silvestre Frenk Freund, Mexico City, Mexico
Martín-Trejo, JA:
Inst Mexicano Seguro Social IMSS, Hosp Pediat Dr Silvestre Frenk Freund, Ctr Med Nacl Siglo 21, Serv Hematol,Unidad Med Alta Especial UMAE, Mexico City, Mexico
Rodriguez-Cedeño, E:
Inst Mexicano Seguro Social IMSS, Hosp Gen Dr Gaudencio Gonzalez Garza, Ctr Med Nacl Raza, Serv Hematol Pediat,Unidad Med Alta Especial UMAE, Mexico City, Mexico
Bekker-Méndez, VC:
Hosp Infectol Dr Daniel Mendez Hernandez, Unidad Invest Med Inmunol & Infectol, Inst Mexicano Seguro Social IMSS, Mexico City, Mexico
Romero-Tlalolini, MD:
Univ Autonoma Benito Juarez de Oaxaca, Lab Fibrosis & Canc, Fac Med & Cirugia, Oaxaca, Oaxaca, Mexico
Cruz-Maza, A:
Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Unidad Desarrollo Invest Bioterapeut UDIBI, Mexico City, Mexico
Labs Juarez Oaxaca, Oaxaca, Mexico
Juarez-Avendaño, G:
Labs Juarez Oaxaca, Oaxaca, Mexico
Pérez-Tapia, SM:
Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Unidad Desarrollo Invest Bioterapeut UDIBI, Mexico City, Mexico
Rodríguez-Espinosa, JC:
Univ Popular Autonoma Estado Puebla, Ctr Invest Oncol Nueva Esperanza, Puebla, Mexico
Suárez-Aguirre, MC:
Univ Popular Autonoma Estado Puebla, Ctr Invest Oncol Nueva Esperanza, Puebla, Mexico
Univ Popular Autonoma Estado Puebla, Fac Biotecnol, Puebla, Mexico
Herrera-Quezada, F:
Hosp Pediat Dr Silvestre Frenk Freund, Ctr Med Nacl Siglo 21, Unidad Invest Med Epidemiol Clin, Inst Mexicano Seguro Social IMSS,Unidad Med Alta E, Mexico City, Mexico
Hernández-Díaz, A:
Hosp Pediat Dr Silvestre Frenk Freund, Ctr Med Nacl Siglo 21, Unidad Invest Med Epidemiol Clin, Inst Mexicano Seguro Social IMSS,Unidad Med Alta E, Mexico City, Mexico
Galván-González, LA:
Hosp Pediat Dr Silvestre Frenk Freund, Ctr Med Nacl Siglo 21, Unidad Invest Med Epidemiol Clin, Inst Mexicano Seguro Social IMSS,Unidad Med Alta E, Mexico City, Mexico
Mata-Rocha, M:
Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Siglo 21, Unidad Invest Med Nutr, Mexico City, Mexico
Olivares-Sosa, AI:
Hosp Pediat Dr Silvestre Frenk Freund, Ctr Med Nacl Siglo 21, Direcc Educ Invest, Inst Mexicano Seguro Social IMSS,Unidad Med Alta E, Mexico City, Mexico
Rosas-Vargas, H:
Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Siglo 21, Unidad Invest Med Nutr, Mexico City, Mexico
Jimenez-Morales, S:
Inst Nacl Med Genomica INMEGEN, Lab Innovac & Med Precis, Nucleo A, Mexico City, Mexico
Cárdenas-González, M:
Consejo Nacl Human Ciencias & Tecnol CONAHCYT, Mexico City, Mexico
Roces, MEAB:
Consejo Nacl Human Ciencias & Tecnol CONAHCYT, Mexico City, Mexico
Duque-Molina, C:
Inst Mexicano Seguro Social IMSS, Dept Dermatol & Micol Med, Mexico City, Mexico
Pelayo, R:
Inst Mexicano Seguro Social IMSS, Ctr Invest Biomed Oriente CIBIOR, Unidad Oncoinmunol & Cit, Puebla, Mexico
Inst Mexicano Seguro Social, Unidad Invest Med Otoneurol, Mexico City 06720, Mexico
Mejia-Aranguré, JM:
Inst Nacl Med Genom INMEGEN, Lab Genomica Canc, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Mexico City, Mexico
Nunez-Enriquez, JC:
Hosp Pediat Dr Silvestre Frenk Freund, Ctr Med Nacl Siglo 21, Unidad Invest Med Epidemiol Clin, Inst Mexicano Seguro Social IMSS,Unidad Med Alta E, Mexico City, Mexico
Hosp Pediat Dr Silvestre Frenk Freund, Ctr Med Nacl Siglo 21, Direcc Educ Invest, Inst Mexicano Seguro Social IMSS,Unidad Med Alta E, Mexico City, Mexico
gold, All Open Access; Gold Open Access
|