Disturbances in the IgG Antibody Profile in HIV-Exposed Uninfected Infants Associated with Maternal Factors
Por:
Camacho-Pacheco R.T., Hernández-Pineda J., Brito-Pérez Y., Plazola-Camacho N., Coronado-Zarco I.A., Arreola-Ramírez G., Bermejo-Haro M.Y., Najera-Hernández M.A., González-Pérez G., Herrera-Salazar A., Olmos-Ortiz A., Soriano-Becerril D., Sandoval-Montes C., Figueroa-Damian R., Rodríguez-Martínez S., Mancilla-Herrera I.
Publicada:
1 ene 2024
Resumen:
Over the last 20 years, the incidence of vertical HIV transmission has decreased from 25%-42% to less than 1%. Although there are no signs of infection, the health of HIV-exposed uninfected (HEU) infants is notoriously affected during the first months of life, with opportunistic infections being the most common disease. Some studies have reported effects on the vertical transfer of antibodies, but little is known about the subclass distribution of these antibodies. We proposed to evaluate the total IgG concentration and its subclasses in HIV+ mothers and HEU pairs and to determine which maternal factors condition their levels. In this study, plasma from 69 HEU newborns, their mothers, and 71 control pairs was quantified via immunoassays for each IgG isotype. Furthermore, we followed the antibody profile of HEUs throughout the first year of life. We showed that mothers present an antibody profile characterized by high concentrations of IgG1 and IgG3 but reduced IgG2, and HEU infants are born with an IgG subclass profile similar to that of their maternal pair. Interestingly, this passively transferred profile could remain influenced even during their own antibody production in HEU infants, depending on maternal conditions such as CD4+ T-cell counts and maternal antiretroviral treatment. Our findings indicate that HEU infants exhibit an altered IgG subclass profile influenced by maternal factors, potentially contributing to their increased susceptibility to infections. Copyright © 2024 Rodrigo T. Camacho-Pacheco et al.
Filiaciones:
Camacho-Pacheco R.T.:
Infectology and Immunology Department, National Institute of Perinatology (INPer), Mexico City, Mexico
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Mexico
Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Mexico City, Mexico
Hernández-Pineda J.:
Infectology and Immunology Department, National Institute of Perinatology (INPer), Mexico City, Mexico
Brito-Pérez Y.:
Infectology and Immunology Department, National Institute of Perinatology (INPer), Mexico City, Mexico
Plazola-Camacho N.:
Infectology and Immunology Department, National Institute of Perinatology (INPer), Mexico City, Mexico
Coronado-Zarco I.A.:
Neonatology Department, National Institute of Perinatology (INPer), Mexico City, Mexico
Arreola-Ramírez G.:
Neonatology Department, National Institute of Perinatology (INPer), Mexico City, Mexico
Bermejo-Haro M.Y.:
Infectology and Immunology Department, National Institute of Perinatology (INPer), Mexico City, Mexico
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Mexico
Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Mexico City, Mexico
Najera-Hernández M.A.:
Infectology and Immunology Department, National Institute of Perinatology (INPer), Mexico City, Mexico
González-Pérez G.:
Department of Physiology and Cellular Development, National Institute of Perinatology (INPer), Mexico City, Mexico
Herrera-Salazar A.:
Unidad de Investigación Multidisciplinaria, Facultad de Estudios Superiores Cuautitlán, UNAM, Cuautitlán Izcalli, Mexico
Olmos-Ortiz A.:
Immunobiochemistry Department, National Institute of Perinatology (INPer), Mexico City, Mexico
Soriano-Becerril D.:
Infectology and Immunology Department, National Institute of Perinatology (INPer), Mexico City, Mexico
Sandoval-Montes C.:
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Mexico
Figueroa-Damian R.:
Infectology and Immunology Department, National Institute of Perinatology (INPer), Mexico City, Mexico
Rodríguez-Martínez S.:
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Mexico
Mancilla-Herrera I.:
Infectology and Immunology Department, National Institute of Perinatology (INPer), Mexico City, Mexico
All Open Access; Gold Open Access
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