Unveiling cellular vitality: peptide fluorescent probes illuminate mitochondrial dynamics and ROS activity

Por: Vázquez-Sandoval, I, Bernal-Escalante, J, Romo-Pérez, A, Jimenez-Sánchez, A

Publicada: 18 ene 2024

Web: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85178574402&doi=10.1039%2fd3sd00279a&partnerID=40&md5=532e4d51d5462c1295383bd5280d8f98

Resumen:
This study explored cell-penetrating peptide probes for dynamic cellular vitality tracking. In particular, two mitochondrial-penetrating peptide probes effectively monitored changes in mitochondrial morphology and ROS activity, serving as reliable vitality indicators. Dual-confocal channel monitoring and spectrally-resolved confocal microscopy were employed to trace local structural changes during probe photooxygenation induced by mitochondrial ROS. This study explored cell-penetrating peptide probes for dynamic cellular vitality tracking.

Filiaciones:
Vázquez-Sandoval, I:
Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ,Circuito Exterior S-N, Ciudad De Mexico 04510, Coyoacan, Mexico

Bernal-Escalante, J:
Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ,Circuito Exterior S-N, Ciudad De Mexico 04510, Coyoacan, Mexico

Romo-Pérez, A:
Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ,Circuito Exterior S-N, Ciudad De Mexico 04510, Coyoacan, Mexico

Jimenez-Sánchez, A:
Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ,Circuito Exterior S-N, Ciudad De Mexico 04510, Coyoacan, Mexico

ISSN: 26350998

Sensors & Diagnostics

Editorial
ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND

Tipo de documento: Article
Volumen: 3 Número: 1
Páginas: 59-63

DOI: 10.1039/d3sd00279a

WOS Id: 001144192300001

Unveiling cellular vitality: peptide fluorescent probes illuminate mitochondrial dynamics and ROS activity

MÉTRICAS