Characterization of sperm motility and testosterone secretion in the taiep myelin mutant, a model of demyelination
Por:
de la Torre, LPM, Hernández, AT, Eguibar, JR, Cortés, C, Morales-Ledesma, L
Publicada:
1 ene 2023
Resumen:
Presently, demyelinating diseases have been reported to affect the reproductive life of patients who suffer from them, but the progression of the alterations is unknown, especially in men. To better understand these effects, it is necessary to perform studies in animal models, such as the male taiep rat, which exhibits progressive demyelination of the central nervous system, altered kisspeptin expression at the hypothalamic level, and decreased luteinizing hormone, which could alter sperm quality and testicular diameter. Thus, the objective of the present study was to analyze the diameter of the seminiferous tubules, the sperm motility, and the testosterone levels of 90-day-old male taiep rats. The obtained results indicate that male taiep rats show an increase in testicular size accompanied by an increase in the diameter of the seminiferous tubules of the left testicle. There was also a decrease in progressive motility in sperm samples from the left epididymis of male taiep rats compared to the control group, with no changes in serum testosterone concentration. Therefore, we conclude that male taiep rats with central demyelination show altered testicular diameter and decreased motility in sperm from the left side. This type of studies serves as a basis for proposing possible reproductive strategies to improve the fertility and testicular function of men with demyelinating diseases of the central nervous system.
Filiaciones:
de la Torre, LPM:
Univ Nacl Autonoma Mexico, Posgrad Ciencias Biol, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Estudios Super Zaragoza, Unidad Invest Biol Reprod, Lab Fisiol Reprod, Mexico City, Mexico
Hernández, AT:
Benemerita Univ Autonoma Puebla, Inst Ciencias, Puebla, Mexico
Eguibar, JR:
Benemerita Univ Autonoma Puebla, Vicerrectoria Invest & Estudios Posgrad, Puebla, Mexico
Cortés, C:
Benemerita Univ Autonoma Puebla, Inst Fisiol, Puebla, Mexico
Morales-Ledesma, L:
Univ Nacl Autonoma Mexico, Fac Estudios Super Zaragoza, Unidad Invest Biol Reprod, Lab Fisiol Reprod, Mexico City, Mexico
Green Published, gold, All Open Access; Gold Open Access; Green Open Access
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