Antinociceptive and antiedema effects produced in rats by Brassica oleracea var. italica sprouts involving sulforaphane
Por:
Guadarrama-Enríquez O., Moreno-Pérez G.F., González-Trujano M.E., Ángeles-López G.E., Ventura-Martínez R., Díaz-Reval I., Cano-Martínez A., Pellicer F., Baenas N., Moreno D.A., García-Viguera C.
Publicada:
1 ene 2023
Ahead of Print:
1 sep 2023
Resumen:
Natural products are recognized as potential analgesics since many of them are part of modern medicine to relieve pain without serious adverse effects. The aim of this study was to investigate the antinociceptive and anti-inflammatory activities of an aqueous extract of Brassica oleracea var. italica sprouts (AEBS) and one of its main reported bioactive metabolites sulforaphane (SFN). Antinociceptive activity of the AEBS (30, 100, and 300 mg/kg, i.p. or 1000 and 2000 mg/kg, p.o.) and SFN (0.1 mg/kg, i.p.) was evaluated in the plantar test in rats to reinforce its analgesic-like activity at central level using the reference drug tramadol (TR, 50 mg/kg, i.p.). The anti-inflammatory-like response was determined in the carrageenan-induced oedema at the same dosages for comparison with ketorolac (KET, 20 mg/kg, i.p.) or indomethacin (INDO, 20 mg/kg, p.o.). A histological analysis of the swollen paw was included to complement the anti-inflammatory response. Additionally, acute toxicity observed in clinical analgesics as the most common adverse effects, such as sedation and/or gastric damage, was also explored. As a result, central and peripheral action of the AEBS was confirmed using enteral and parenteral administration, in which significant reduction of the nociceptive and inflammatory responses resembled the effects of TR, KET, or INDO, respectively, involving the presence of SFN. No adverse or toxic effects were observed in the presence of the AEBS or SFN. In conclusion, this study supports that Brassica oleracea var. italica sprouts are a potential source of antinociceptive natural products such as SFN for therapy of pain alone and associated to an inflammation condition. © 2023, The Author(s).
Filiaciones:
Guadarrama-Enríquez O.:
Laboratorio de Neurofarmacología de Productos Naturales. Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría “Ramón de La Fuente Muñiz”, Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Ciudad de Mexico, Tlalpan. C.P, 14370, Mexico
Moreno-Pérez G.F.:
Laboratorio de Neurofarmacología de Productos Naturales. Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría “Ramón de La Fuente Muñiz”, Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Ciudad de Mexico, Tlalpan. C.P, 14370, Mexico
González-Trujano M.E.:
Laboratorio de Neurofarmacología de Productos Naturales. Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría “Ramón de La Fuente Muñiz”, Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Ciudad de Mexico, Tlalpan. C.P, 14370, Mexico
Ángeles-López G.E.:
Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Av. Universidad No. 3000, Col. Ciudad Universitaria, Ciudad de Mexico, Alcaldía Coyoacán, 04510, Mexico
Ventura-Martínez R.:
Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Av. Universidad No. 3000, Col. Ciudad Universitaria, Ciudad de Mexico, Alcaldía Coyoacán, 04510, Mexico
Díaz-Reval I.:
Laboratorio de “Farmacología del Dolor” del Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Av. 25 de Julio 965, Colima, Col, 28045, Mexico
Cano-Martínez A.:
Departamento de Fisiología, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano 1, Col. Sección XVI, Ciudad de Mexico, Tlalpan. C.P, 14080, Mexico
Pellicer F.:
Laboratorio de Neurofarmacología de Productos Naturales. Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría “Ramón de La Fuente Muñiz”, Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Ciudad de Mexico, Tlalpan. C.P, 14370, Mexico
Baenas N.:
Department of Food Technology, Food Science and Nutrition, Faculty of Veterinary Sciences, Regional Campus of International Excellence “Campus Mare Nostrum”, Biomedical Research Institute of Murcia (IMIB-Arrixaca-UMU), University of Murcia, Espinardo, Murcia, 30100, Spain
Moreno D.A.:
Laboratorio de Fitoquímica y Alimentos Saludables (LabFAS), CEBAS, CSIC, Campus de Espinardo - 25, Murcia, 30100, Spain
García-Viguera C.:
Laboratorio de Fitoquímica y Alimentos Saludables (LabFAS), CEBAS, CSIC, Campus de Espinardo - 25, Murcia, 30100, Spain
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