Liver transplant in primary sclerosing cholangitis: Current trends and future directions
Por:
Shah, Yash R., Nombera-Aznaran, Natalia, Guevara-Lazo, David, Calderon-Martinez, Ernesto, Tiwari, Angad, Kanumilli, Srilakshmidevi, Shah, Purva, Pinnam B.S.M., Ali, Hassam, Dahiya, Dushyant Singh
Publicada:
1 ene 2023
Categoría:
Hepatology
Resumen:
Primary sclerosing cholangitis (PSC) is a chronic and progressive immunemediated cholangiopathy causing biliary tree inflammation and scarring, leading to liver cirrhosis and end-stage liver disease. Diagnosis of PSC is challenging due to its nonspecific symptoms and overlap with other liver diseases. Despite the rising incidence of PSC, there is no proven medical therapy that can alter the natural history of the disease. While liver transplantation (LT) is the most effective approach for managing advanced liver disease caused by PSC, post-transplantation recurrence of PSC remains a challenge. Therefore, ongoing research aims to develop better therapies for PSC, and continued efforts are necessary to improve outcomes for patients with PSC. This article provides an overview of PSC’s pathogenesis, clinical presentation, and management options, including LT trends and future aspects. It also highlights the need for improved therapeutic options and ethical considerations in providing equitable access to LT for patients with PSC. Additionally, the impact of liver transplant on the quality of life and psychological outcomes of patients with PSC is discussed. Ongoing research into PSC’s pathogenesis and post-transplant recurrence is crucial for improved understanding of the disease and more effective treatment options. © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Filiaciones:
Shah, Yash R.:
Department of Internal Medicine, Trinity Health Oakland, Pontiac, MI 48341, United States
Trinity Hlth Oakland, Dept Internal Med, Pontiac, MI 48341 USA
Nombera-Aznaran, Natalia:
Faculty of Medicine, Universidad Peruana Cayetano Heredia, Lima, 15102, Peru
Univ Peruana Cayetano Heredia, Fac Med, Lima 15102, Peru
Guevara-Lazo, David:
Faculty of Medicine, Universidad Peruana Cayetano Heredia, Lima, 15102, Peru
Univ Peruana Cayetano Heredia, Fac Med, Lima 15102, Peru
Calderon-Martinez, Ernesto:
Department of Internal Medicine, Universidad Nacional Autonoma de Mexico, Ciudad De Mexico, 04510, Mexico
Univ Nacl Autonoma Mexico, Dept Internal Med, Mexico City 04510, Mexico
Tiwari, Angad:
Department of Internal Medicine, Maharani Laxmi Bai Medical College, Jhansi, 284001, India
Maharani Laxmi Bai Med Coll, Dept Internal Med, Jhansi 284001, India
Kanumilli, Srilakshmidevi:
Department of Internal Medicine, GSL Medical College, Rajamahendravaram, 533296, India
GSL Med Coll, Dept Internal Med, Rajamahendravaram 533296, India
Shah, Purva:
Department of Postgraduate Education, Harvard Medical School, Boston, MA 02115, United States
Harvard Med Sch, Dept Postgrad Educ, Boston, MA 02215 USA
Pinnam B.S.M.:
Department of Internal Medicine, John H. Stroger Hospital of Cook County, Chicago, IL 60612, United States
Ali, Hassam:
Department of Internal Medicine, East Carolina University/Brody School of Medicine, Greenville, NC 27858, United States
East Carolina Univ, Brody Sch Med, Dept Internal Med, Greenville, NC 27858 USA
Dahiya, Dushyant Singh:
Division of Gastroenterology, Hepatology and Motility, The University of Kansas School of Medicine, Kansas City, KS 66160, United States
Univ Kansas, Div Gastroenterol Hepatol & Motil, Sch Med, Kansas City, KS 66160 USA
Univ Kansas, Sch Med, Div Gastroenterol Hepatol & Motil, 2000 Olathe Blvd, Kansas City, KS 66160 USA
John H Stroger Hosp Cook Cty, Dept Internal Med, Chicago, IL 60612 USA
Green Published, gold, Gold
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