Meta-analysis to Implement Alpha-Synuclein in Extracellular Vesicles as a Potential Biomarker for Parkinsons Disease
Por:
Juárez-Vaquera V.H., Rosetti-Sciutto M.F., Morales-Ruiz V., Adalid-Peralta L.V.
Publicada:
1 ene 2023
Categoría:
Medicine (miscellaneous)
Resumen:
Background: In Parkinson's disease (PD), exosomes carry a-synuclein (a-syn), a fibrillar protein aggregates with potential value as a biomarker. Objective: Evidence on blood levels of exosomal a-syn in PD patients and controls was reviewed for their consistency. Methods: Thirty-six studies on exosomal a-syn concentrations in PD were identified in a systematic literature search and meta-analysis. Results: Both raw and ratio-adjusted blood exosomal a-syn levels were consistently higher in PD patients than in controls. The standardized mean difference (SMD) was 1.54 (0.18-2.90, CI95%, p < 0.01) and 1.53 (0.23-2.83, CI95%, p < 0.01), respectively. Conclusion: Our results suggest that exosomal a-syn concentrations could be a useful biomarker for PD. Copyright: © 2023 Permanyer.
Filiaciones:
Juárez-Vaquera V.H.:
Unidad Periférica para el Estudio de la Neuroinflamación en Patologías Neurológicas, Instituto de Investigaciones Biomédicas, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez (INNNMVS)Mexico City, Mexico
Rosetti-Sciutto M.F.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoMexico City, Mexico
Morales-Ruiz V.:
Unidad Periférica para el Estudio de la Neuroinflamación en Patologías Neurológicas, Instituto de Investigaciones Biomédicas, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez (INNNMVS)Mexico City, Mexico
Adalid-Peralta L.V.:
Unidad Periférica para el Estudio de la Neuroinflamación en Patologías Neurológicas, Instituto de Investigaciones Biomédicas, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez (INNNMVS)Mexico City, Mexico
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