The hepatic effects of GDF11 on health and disease
Por:
Gerardo-Ramirez, Monserrat, German-Ramirez, Natanael, Escobedo-Calvario, Alejandro, Chavez-Rodriguez, Lisette, Bucio-Ortiz, Leticia, Souza-Arroyo, Ver onica, Miranda-Labra, Roxana U., Gutierrez-Ruiz, Maria Concepcion, Gomez-Quiroz, Luis E.
Publicada:
1 ene 2023
Resumen:
The growth differentiation factor 11 (GDF11), a member of the superfamily of the transforming growth factor ß, has gained relevance in the last few years due to its remarkable effects in cellular biology, particularly in the nervous system, skeletal muscle, the heart, and many epithelial tissues. Some controversies have been raised about this growth factor. Many of them have been related to technical factors but also the nature of the cellular target. In liver biology and pathobiology, the GDF11 has shown to be related in many molecular aspects, with a significant impact on the physiology and the initiation and progression of the natural history of liver diseases. GDF11 has been involved as a critical regulator in lipid homeostasis, which, as it is well known, is the first step in the progression of liver disease. However, also it has been reported that the GDF11 is involved in fibrosis, senescence, and cancer. Although there are some controversies, much of the literature indicates that GDF11 displays effects tending to solve or mitigate pathological states of the liver, with reasonable evidence of correlation with other organs or systems. To a large extent, the controversy, as mentioned, is due to technical problems, such as the specificity of GDF11 antibodies, confusion with its closer family member, myostatin, and the state of differentiation in the tissues. In the present work, we reviewed the specific effects of GDF11 in the biology and pathobiology of the liver as a potential and promising factor for therapeutic intervention shortly. © 2022 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM)
Filiaciones:
Gerardo-Ramirez, Monserrat:
Laboratorio de Medicina Experimental y Carcinogénesis, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, Mexico
First Department of Internal Medicine, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Lab Med Expt & Carcinogenesis, Mexico City, Mexico
Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Internal Med 1, Mainz, Germany
German-Ramirez, Natanael:
Laboratorio de Medicina Experimental y Carcinogénesis, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, Mexico
Posgrado en Biología Experimental, DCBS, Universidad Autónoma Metrolitana-Iztapalapa, Mexico City, Mexico
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Lab Med Expt & Carcinogenesis, Mexico City, Mexico
Univ Autonoma Metrolitana Iztapalapa, Posgrad Biol Expt, DCBS, Mexico City, Mexico
Escobedo-Calvario, Alejandro:
Laboratorio de Medicina Experimental y Carcinogénesis, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, Mexico
Posgrado en Biología Experimental, DCBS, Universidad Autónoma Metrolitana-Iztapalapa, Mexico City, Mexico
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Lab Med Expt & Carcinogenesis, Mexico City, Mexico
Univ Autonoma Metrolitana Iztapalapa, Posgrad Biol Expt, DCBS, Mexico City, Mexico
Chavez-Rodriguez, Lisette:
Laboratorio de Medicina Experimental y Carcinogénesis, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, Mexico
Posgrado en Biología Experimental, DCBS, Universidad Autónoma Metrolitana-Iztapalapa, Mexico City, Mexico
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Lab Med Expt & Carcinogenesis, Mexico City, Mexico
Univ Autonoma Metrolitana Iztapalapa, Posgrad Biol Expt, DCBS, Mexico City, Mexico
Bucio-Ortiz, Leticia:
Laboratorio de Medicina Experimental y Carcinogénesis, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, Mexico
Laboratorio de Medicina Experimental, Unidad de Medicina Traslacional IIB/UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Lab Med Expt & Carcinogenesis, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Lab Med Expt, Unidad Med Traslac IIB, Inst Nacl Cardiol Ignacio Chavez, Mexico City, Mexico
Souza-Arroyo, Ver onica:
Laboratorio de Medicina Experimental y Carcinogénesis, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, Mexico
Laboratorio de Medicina Experimental, Unidad de Medicina Traslacional IIB/UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Lab Med Expt & Carcinogenesis, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Lab Med Expt, Unidad Med Traslac IIB, Inst Nacl Cardiol Ignacio Chavez, Mexico City, Mexico
Miranda-Labra, Roxana U.:
Laboratorio de Medicina Experimental y Carcinogénesis, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, Mexico
Laboratorio de Medicina Experimental, Unidad de Medicina Traslacional IIB/UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Lab Med Expt & Carcinogenesis, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Lab Med Expt, Unidad Med Traslac IIB, Inst Nacl Cardiol Ignacio Chavez, Mexico City, Mexico
Gutierrez-Ruiz, Maria Concepcion:
Laboratorio de Medicina Experimental y Carcinogénesis, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, Mexico
Laboratorio de Medicina Experimental, Unidad de Medicina Traslacional IIB/UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Lab Med Expt & Carcinogenesis, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Lab Med Expt, Unidad Med Traslac IIB, Inst Nacl Cardiol Ignacio Chavez, Mexico City, Mexico
Gomez-Quiroz, Luis E.:
Laboratorio de Medicina Experimental y Carcinogénesis, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, Mexico
Laboratorio de Medicina Experimental, Unidad de Medicina Traslacional IIB/UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Lab Med Expt & Carcinogenesis, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Lab Med Expt, Unidad Med Traslac IIB, Inst Nacl Cardiol Ignacio Chavez, Mexico City, Mexico
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