Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar rats
Por:
Salas-Venegas, Veronica, Santin-Marquez, Roberto, Jair Ramirez-Carreto, Ricardo, Maria Rodriguez-Cortes, Yesica, Cano-Martinez, Agustina, Luna-Lopez, Armando, Chavarria, Anahi, Konigsberg, Mina, Edith Lopez-Diazguerrero, Norma
Publicada:
17 abr 2023
Resumen:
Being overweight and obesity are world health problems, with a higher
prevalence in women, defined as abnormal or excessive fat accumulation
that increases the risk of chronic diseases. Excess energy leads to
adipose expansion, generating hypertrophic adipocytes that produce
various pro-inflammatory molecules. These molecules cause chronic
low-intensity inflammation, affecting the organism's functioning and the
central nervous system (CNS), inducing neuroinflammation. The
neuroinflammatory response during obesity occurs in different structures
of the CNS involved in memory and learning, such as the cortex and the
hippocampus. Here we analyzed how obesity-related peripheral
inflammation can affect CNS physiology, generating neuroinflammation and
promoting cellular senescence establishment. Since some studies have
shown an increase in senescent cells during aging, obesity, and
neurodegenerative diseases, we proposed that cellular senescence
participation may contribute to the cognitive decline in an obesity
model of middle-aged female Wistar rats. The inflammatory state of 6 and
13 months-old female Wistar rats fed with a hypercaloric diet was
measured in serum and CNS (cortex and hippocampus). Memory was evaluated
using the novel object recognition (NOR) test; the presence of senescent
markers was also determined. Our data suggest that the systemic
inflammation generated by obesity induces a neuroinflammatory state in
regions involved in learning and memory, with an increase in senescent
markers, thus proposing senescence as a potential participant in the
negative consequences of obesity in cognition.
Filiaciones:
Salas-Venegas, Veronica:
Univ Autonoma Metropolitana, Unidad Iztapalapa, Posgrad Biol Expt, Mexico City, Mexico
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Div Ciencias Biol & Salud DCBS, Mexico City, Mexico
Santin-Marquez, Roberto:
Univ Autonoma Metropolitana, Unidad Iztapalapa, Posgrad Biol Expt, Mexico City, Mexico
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Div Ciencias Biol & Salud DCBS, Mexico City, Mexico
Jair Ramirez-Carreto, Ricardo:
Univ Nacl Autonoma Mexico, Programa Doctorado Ciencias Biomed, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Mexico City, Mexico
Maria Rodriguez-Cortes, Yesica:
Univ Nacl Autonoma Mexico, Programa Doctorado Ciencias Biomed, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Mexico City, Mexico
Cano-Martinez, Agustina:
Inst Nacl Cardiol Ignacio Chavez, Dept Fisiol, Mexico City, Mexico
Luna-Lopez, Armando:
Inst Nacl Geriatria, Dept Invest Bas, Mexico City, Mexico
Chavarria, Anahi:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Mexico City, Mexico
Konigsberg, Mina:
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Div Ciencias Biol & Salud DCBS, Mexico City, Mexico
Edith Lopez-Diazguerrero, Norma:
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Div Ciencias Biol & Salud DCBS, Mexico City, Mexico
gold, Gold
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