Secondary immunodeficiencies related to the presence of anti-cytokine autoantibodies
Por:
Cortes-Acevedo, Paulina, Mendoza-Elvira, Susana E., Doffinger, Rainer, Barcenas-Morales, Gabriela
Publicada:
1 mar 2023
Categoría:
Medicine (miscellaneous)
Resumen:
Anti-cytokine autoantibodies (ACAA) have been reported to be an
important cause of secondary immunodeficiencies. High titers of
neutralizing autoantibodies may cause susceptibility to different
life-threatening infectious diseases. For example, neutralizing
autoantibodies against IFN gamma have been reported to be correlated
with susceptibility to mycobacterial infections and intracellular fungal
pathogens. Autoantibodies against IL-6 were detected in patients with
subcutaneous abscesses and recur-rent staphylococcal cellulitis; on the
other hand, patients with cryptococcosis, nocardiosis, and pulmonary
alveolar proteinosis were positive for autoantibodies to GM-CSF. A
relationship has also been established between autoantibodies against
IL-17 and IL-22 and chronic mucosal Candida infections, which have been
identified in patients with APECED or thymoma. Autoan-tibodies against
type-I IFN have been recently reported during the onset of acute
COVID-19. These ACAAs resemble genetic defects in cytokines or their
signaling pathways. Therefore, they may be considered to be primary
immunodeficiencies phenocopies. Consequently, the detection of ACAA
could be important in the diagnosis of patients, particularly in the
case of late-onset diseases, in order to decide appropriate treatments.
This review presents an overview of current understanding of
ACAA-associated secondary immunodeficiencies.
Filiaciones:
Cortes-Acevedo, Paulina:
Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Lab Inmunol 2, Mexico City, Estado De Mexic, Mexico
Mendoza-Elvira, Susana E.:
Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Lab Virol 3, Mexico City, Estado De Mexic, Mexico
Doffinger, Rainer:
Addenbrookes Hosp, Dept Bioquim Clin & Inmunol, Cambridge, England
Barcenas-Morales, Gabriela:
Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Lab Inmunol 2, Mexico City, Estado De Mexic, Mexico
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