Heart rate is associated with markers of fatty acid desaturation: The GOCADAN study
Por:
Ebbesson S.O.E., Lopez-Alvarenga J.C., Okin P.M., Devereux R.B., Tejero M.E., Harris W.S., Ebbesson L.O.E., Maccluer J.W., Wenger C., Laston S., Fabsitz R.R., Kennish J., Howard W.J., Howard B.V., Umans J., Comuzzie A.G.
Publicada:
1 ene 2012
Resumen:
Objectives: To determine if heart rate (HR) is associated with desaturation indexes as HR is associated with arrhythmia and sudden death. Study design: A community based cross-sectional study of 1214 Alaskan Inuit. Methods: Data of FA concentrations from plasma and red blood cell membranes from those =35 years of age (n=819) were compared to basal HR at the time of examination. Multiple linear regression with backward stepwise selection was employed to analyze the effect of the desaturase indexes on HR, after adjustment for relevant covariates. Results: The 5 desaturase index ( 5-DI) measured in serum has recently been associated with a protective role for cardiovascular disease. This index measured here in plasma and red blood cells showed a negative correlation with HR. The plasma stearoyl-CoA-desaturase (SCD) index, previously determined to be related to cardiovascular disease (CVD) mortality, on the other hand, was positively associated with HR, while the D6 desaturase index ( 6-DI) had no significant effect on HR. Conclusion: Endogenous FA desaturation is associated with HR and thereby, in the case of SCD, possibly with arrhythmia and sudden death, which would at least partially explain the previously observed association between cardiovascular mortality and desaturase activity. © 2012 Sven O.E. Ebbesson et al.
Filiaciones:
Ebbesson S.O.E.:
GOCADA, Department, Norton Sound Health Corporation, Nome, AK, United States
Lopez-Alvarenga J.C.:
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, United States
Okin P.M.:
Division of Cardiology, Department of Medicine, Weill Cornell Medical College, New York, NY, United States
Devereux R.B.:
Division of Cardiology, Department of Medicine, Weill Cornell Medical College, New York, NY, United States
Tejero M.E.:
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, United States
Harris W.S.:
South Dakota Health Research Foundation, Nutrition and Metabolic Diseases, Sioux Falls, SD, United States
Ebbesson L.O.E.:
Integrative Fish Biology, Uni Environment, Uni Research, AS, Bergen, Norway
Maccluer J.W.:
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, United States
Wenger C.:
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, United States
Laston S.:
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, United States
Fabsitz R.R.:
Division of Cardiovascular Science, National Heart, Lung, and Blood Institute, Bethesda, MD, United States
Kennish J.:
Department of Chemistry, University of Alaska Anchorage, Anchorage, AK, United States
Howard W.J.:
Penn Medical Lab, MedStar Research Institute, Hyattsville, MD, United States
Howard B.V.:
Penn Medical Lab, MedStar Research Institute, Hyattsville, MD, United States
Umans J.:
Penn Medical Lab, MedStar Research Institute, Hyattsville, MD, United States
Comuzzie A.G.:
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, United States
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