Proteinuria en pacientes con nefropatía diabética y su asociación con síndrome de fragilidad
Por:
Loaiza-Félix J., Huerta-Ramírez S., Elizalde C.I.
Publicada:
1 ene 2015
Categoría:
Internal Medicine
Resumen:
Backgrsound: Overtime the concept of frailty has undergone a series of changes, the above to define it in a better way as a geriatric syndrome. Fried and his colleagues over the last 25 years have defined fragility syndrome and diseases found correlated with the disease. Aging can be defined as a functional individual deterioration due to decreased physiological reserves and the inability to maintain proper interaction with the environment. During the aging process the homeostasis as reserves are lost, the above as a result of a series of alterations in the anabolism of protein, fat and carbohydrates as well as an activation of genes whose reservation results in decreased cell level functioning. Currently the diagnosis of frailty has the Fried scale, which evaluates a series of 5 parameters: strength, weight loss, decreased physical activity, fatigue and decreased physical performance. Although searched a number of markers such as C-reactive protein, interferon, interleukins and leptin have not yet been developed to validate them as prognostic markers of frailty. Objective: To determine if there is a degree of association between proteinuria in patients with diabetic nephropathy and frailty syndrome. Material and method: A descriptive, observational, transversal and analytical study, performed in patients with diabetes mellitus 2 that met criteria of fragility; also were evaluated patients without any underlying disease; then, Freid questionnaire was applied and protein in 24 hours urine was collected. Study was done from August 2012 to December 2013 at General Hospital Ticoman. Results: By the analysis of proteinuria in the control group, in 12 patients no significant proteinuria was found and 23 patients had significant proteinuria; where as in the case group 13 patients had no significant proteinuria and 22 had significant proteinuria, with a p=0.80 for association between proteinuria and frailty with ?2 test. Conclusions: There is not a statistically significant association between the degree of proteinuria and fragility in patients with diabetic nephropathy.
Filiaciones:
Loaiza-Félix J.:
Residente de Cuarto Año de Medicina Interna, Río Amazonas 46, int. 16, México, DF, 06500, Mexico
Huerta-Ramírez S.:
Médico Adscrito al Servicio de Medicina Interna, Hospital General Ticóman, Secretaría de Salud del Distrito Federal, Mexico
Elizalde C.I.:
Médico Adscrito al Servicio de Medicina Interna, Hospital General Ticóman, Secretaría de Salud del Distrito Federal, Mexico
|