Chronic Consumption of Moringa Leaf Powder (Moringa oleifera) Concentration-Dependent Effects in a Drosophila melanogaster Type 2 Diabetes Model
Por:
Lopez-Rodriguez, Norma A., Sanchez-Ortiz, Laura K., Reynoso-Camacho, Rosalia, Riesgo-Escovar, Juan R., Loarca-Pina, Guadalupe
Publicada:
3 abr 2023
Resumen:
Objective The metabolic effects of chronic consumption of food laced
with different doses of moringa leaf powder (MLP) were assessed using a
heteroallelic mutant of the sole insulin receptor gene of Drosophila
melanogaster (InR), and the yellow,white (y,w) control stock. Methods
The MLP composition was partially determined. Both strains were raised
in a standard diet (SD) or in a SD supplemented with different MLP doses
(0.5, 1.5, 2.5, 4.0, and 5.5%) until 4-5 days of emergence. Afterward,
the total carbohydrate, lipid, glucose, and triacylglyceride levels were
measured in the flies. Additionally, survival and weight changes were
reported. For metabolic tests, female and male virgin flies were
evaluated separately. Results Low MLP supplementation improved
carbohydrate and glucose levels in the y,w strain. Additionally, the
InR-mutant strain reported lower lipid content when subjected to the
same regimes. Survival improved in both strains with low MLP doses,
while chronic consumption of high MLP doses resulted in
triacylglycerides increase, weight gain, and survival reduction.
Conclusion Low doses of MLP supplementation improves some metabolic
parameters that affect flies' survival, especially in the y,w strain.
Furthermore, the same low doses of MLP treatments also resulted in
metabolic improvements in the InR-mutant flies; however, MLP consumption
levels should be carefully assessed. Supplemental data for this article
is available online at
Filiaciones:
Lopez-Rodriguez, Norma A.:
Programa de Posgrado en Alimentos del Centro de la República, Research and Graduate Studies in Food Science, School of Chemistry, Universidad Autónoma de Querétaro, Centro Universitario, Qro, Santiago de Querétaro, Mexico
Univ Autonoma Queretaro, Ctr Univ, Sch Chem, Santiago De Queretaro, Qro, Mexico
Sanchez-Ortiz, Laura K.:
Programa de Posgrado en Alimentos del Centro de la República, Research and Graduate Studies in Food Science, School of Chemistry, Universidad Autónoma de Querétaro, Centro Universitario, Qro, Santiago de Querétaro, Mexico
Univ Autonoma Queretaro, Ctr Univ, Sch Chem, Santiago De Queretaro, Qro, Mexico
Reynoso-Camacho, Rosalia:
Programa de Posgrado en Alimentos del Centro de la República, Research and Graduate Studies in Food Science, School of Chemistry, Universidad Autónoma de Querétaro, Centro Universitario, Qro, Santiago de Querétaro, Mexico
Univ Autonoma Queretaro, Ctr Univ, Sch Chem, Santiago De Queretaro, Qro, Mexico
Riesgo-Escovar, Juan R.:
Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Juriquilla, Mexico
Univ Nacl Autonoma Mex, Dept Neurobiol Desarrollo & Neurofisiol, Inst Neurobiol, Juriquilla, Queretaro, Mexico
Univ Nacl autonoma mex, Dept Neurobiol Desarrollo & neurofisiol, Inst Neurobiol, Juriquilla 76230, Queretaro, Mexico
Loarca-Pina, Guadalupe:
Programa de Posgrado en Alimentos del Centro de la República, Research and Graduate Studies in Food Science, School of Chemistry, Universidad Autónoma de Querétaro, Centro Universitario, Qro, Santiago de Querétaro, Mexico
Univ Autonoma Queretaro, Ctr Univ, Sch Chem, Santiago De Queretaro, Qro, Mexico
Univ autonoma Queretaro, Ctr Univ, Sch Chem, cerro campanas S-N, Santiago De Queretaro 76010, Qro, Mexico
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