The burden of mild asthma: Clinical burden and healthcare resource utilisation in the NOVELTY study
Por:
Golam S.M., Janson C., Beasley R., Chipps B., Hughes R., Müllerová H., Olaguibel J.M., Rapsomaniki E., Reddel H.K., Sadatsafavi M., Benhabib G., Mandhane P., Ruiz X.B., McIvor A., Olmo R.D., Pek B., Lisanti R.E., Petrella R., Marino G., Stollery D., Mattarucco W., Chen M., Nogueira J., Chen Y., Parody M., Gu W., Pascale P., Hui K.M.C., Rodriguez P., Li M., Silva D., Li S., Svetliza G., Ma L., Victorio C.F., Qin G., Rolon R.W., Song W., Yañez A., Tan W., Baines S., Tang Y., Bowler S., Wang C., Bremner P., Wang T., Bull S., Wen F., Carroll P., Wu F., Chaalan M., Xiang P., Farah C., Xiao Z., Hammerschlag G., Xiong S., Hancock K., Harrington Z., Yang J., Katsoulotos G., Zhang C., Kim J., Zhang M., Langton D., Zhang P., Zhang W., Peters M., Zheng X., Prassad L., Zhu D., Reddel H., Bolivar Grimaldos F., Sajkov D., Arboleda A.C., Santiago F., Bueno C.M., Simpson F.G., Molina de Salazar D., Tai S., Bendstrup E., Thomas P., Hilberg O., Wark P., Kjellerup C., Cançado J.E.D., Weinreich U., Cunha T., Bonniaud P., Lima M., Brun O., Cardoso A.P., Burgel P.-R., Rabahi M., Chouaid C., Anees S., Couturaud F., Bertley J., de Blic J., Bell A., Debieuvre D., Cheema A., Delsart D., Chouinard G., Demaegdt A., Csanadi M., Demoly P., Dhar A., Deschildre A., Dhillon R., Devouassoux G., FitzGerald J.M., Egron C., Kanawaty D., Falchero L., Kelly A., Goupil F., Killorn W., Kessler R., Landry D., Le Roux P., Luton R., Mabire P., Mahay G., Ide Y., Martinez S., Inomata M., Melloni B., Inoue H., Moreau L., Inoue K., Raherison C., Inoue S., Riviere E., Kato M., Roux-Claudé P., Kawasaki M., Soulier M., Kawayama T., Vignal G., Kita T., Yaici A., Kobayashi K., Aries S.P., Koto H., Bals R., Nishi K., Beck E., Saito J., Deimling A., Shimizu Y., Feimer J., Shirai T., Grimm-Sachs V., Sugihara N., Groth G., Takahashi K.-I., Herth F., Tashimo H., Hoheisel G., Tomii K., Kanniess F., Yamada T., Lienert T., Yanai M., Mronga S., Javier R.C., Reinhardt J., Domínguez Peregrina A., Schlenska C., Corzo M.F., Stolpe C., Montano Gonzalez E., Teber I., Ramírez-Venegas A., Timmermann H., Rendon A., Ulrich T., Boersma W., Velling P., Djamin R.S., Wehgartner-Winkler S., Eijsvogel M., Welling J., Franssen F., Winkelmann E.-J., Goosens M., Barbetta C., Graat-Verboom L., Braido F., Veen J.I., Cardaci V., Janssen R., Clini E.M., Kuppens K., Costantino M.T., van den Berge M., Cuttitta G., van de Ven M., di Gioacchino M., Brunstad O.P., Fois A., Einvik G., Foschino-Barbaro M.P., Høines K.J., Gammeri E., Khusrawi A., Inchingolo R., Oien T., Lavorini F., Chang Y.-S., Molino A., Cho Y.J., Nucera E., Hwang Y.I., Papi A., Kim W.J., Patella V., Koh Y.-I., Pesci A., Lee B.-J., Ricciardolo F., Lee K.-H., Rogliani P., Lee S.-P., Sarzani R., Lee Y.C., Vancheri C., Lim S.Y., Vincenti R., Min K.H., Endo T., Oh Y.-M., Fujita M., Park C.-S., Hara Y., Park H.-S., Horiguchi T., Park H.-W., Hosoi K., Rhee C.K., Yoon H.J., Morice A., Yoon H.-K., Pandya P., García-Navarro A.A., Patel M., Andújar R., Roy K., Anoro L., Sathyamurthy R., García M.B., Thiagarajan S., Mozo P.C., Turner A., Campos S., Vestbo J., Maldonado F.C., Wedzicha W., Castilla Martínez M., Wilkinson T., Serrano C.C., Wilson P., Comeche Casanova L., Al-Asadi L.A., Corbacho D., Anholm J., Campo Matías F.D., Averill F., Echave-Sustaeta J., Bansal S., Corral G.F., Baptist A., Gamboa Setién P., Campbell C., García Clemente M., Campos M.A., Núñez I.G., Robaina J.G., Crook G., García Salmones M., DeLeon S., Marín Trigo J.M., Eid A., Fernandez M.N., Epstein E., Palomo S.N., Fritz S., Olaguibel Rivera J., Harris H., de Llano L.P., Hewitt M., Pueyo Bastida A., Holguin F., Rañó A., Hudes G., Rodríguez González-Moro J., Jackson R., Reig A.R., Kaufman A., Velasco Garrido J., Kaufman D., Curiac D., Klapholz A., Krishna H., Lif-Tiberg C., Lee D., Luts A., Lin R., Råhlen L., Maselli-Caceres D., Rustscheff S., Mehta V., Adams F., Moy J.N., Bradman D., Nwokoro U., Broughton E., Parikh P., Cosgrove J., Parikh S., Flood-Page P., Perrino F., Fuller E., Ruhlmann J., Harrison T., Sassoon C., Hartley D., Settipane R.A., Hattotuwa K., Sousa D., Jones G., Sriram P., Lewis K., Wachs R., McGarvey L.
Publicada:
1 ene 2022
Categoría:
Pulmonary and respiratory medicine
Resumen:
Background: Patients with mild asthma represent a substantial proportion of the population with asthma, yet there are limited data on their true burden of disease. We aimed to describe the clinical and healthcare resource utilisation (HCRU) burden of physician-assessed mild asthma. Methods: Patients with mild asthma were included from the NOVEL observational longiTudinal studY (NOVELTY; NCT02760329), a global, 3-year, real-world prospective study of patients with asthma and/or chronic obstructive pulmonary disease from community practice (specialised and primary care). Diagnosis and severity were based on physician discretion. Clinical burden included physician-reported exacerbations and patient-reported measures. HCRU included inpatient and outpatient visits. Results: Overall, 2004 patients with mild asthma were included; 22.8% experienced =1 exacerbation in the previous 12 months, of whom 72.3% experienced =1 severe exacerbation. Of 625 exacerbations reported, 48.0% lasted >1 week, 27.7% were preceded by symptomatic worsening lasting >3 days, and 50.1% required oral corticosteroid treatment. Health status was moderately impacted (St George's Respiratory Questionnaire score: 23.5 [standard deviation ± 17.9]). At baseline, 29.7% of patients had asthma symptoms that were not well controlled or very poorly controlled (Asthma Control Test score <20), increasing to 55.6% for those with =2 exacerbations in the previous year. In terms of HCRU, at least one unscheduled ambulatory visit for exacerbations was required by 9.5% of patients, including 9.2% requiring =1 emergency department visit and 1.1% requiring =1 hospital admission. Conclusions: In this global sample representing community practice, a significant proportion of patients with physician-assessed mild asthma had considerable clinical burden and HCRU. © 2022 The Authors
Filiaciones:
Golam S.M.:
GMAP, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
Janson C.:
Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden
Beasley R.:
Medical Research Institute of New ZealandWellington, New Zealand
Chipps B.:
Capital Allergy and Respiratory Disease Center, Sacramento, CA, United States
Hughes R.:
External Scientific Engagement, BioPharmaceuticals Medical, AstraZeneca, Cambridge, United Kingdom
Müllerová H.:
Respiratory & Immunology, Medical and Payer Evidence Strategy, BioPharmaceuticals Medical, AstraZeneca, Cambridge, United Kingdom
Olaguibel J.M.:
Severe Asthma Unit, Complejo Hospitalario de Navarra, Pamplona, Spain
Rapsomaniki E.:
Real World Data Science, BioPharmaceuticals Medical, AstraZeneca, Cambridge, United Kingdom
Reddel H.K.:
The Woolcock Institute of Medical Research and the University of Sydney, Sydney, Australia
Sadatsafavi M.:
Respiratory Evaluation Sciences Program, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
Reddel H.:
The Woolcock Institute of Medical Research and the University of Sydney, Sydney, Australia
FitzGerald J.M.:
Centre for Lung Health, The Lung Centre, Vancouver General Hospital, Vancouver Coastal Health Research Institute, Vancouver, Canada
Harrison T.:
Faculty of Medicine and Health Sciences, Nottingham City Hospital, Nottingham, United Kingdom
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