Variation in the Production of Sedative and Anxiolytic Compounds Among Galphimia sp. Populations Grown in a Greenhouse
Por:
Balderas G.S., Alcalá R.E., Ortíz-Caltempa A., Cardoso-Taketa A., Villarreal M.L.
Publicada:
1 ene 2020
Categoría:
Pharmacology, toxicology and pharmaceutics (miscellaneous)
Resumen:
Galphimia glauca Cav., Malpighiaceae, is used as a tranquilizer in Mexico. Its active compounds are nor-secofriedelane triterpenes known as galphimines. Using metabolic profiling, we previously demonstrated that individuals obtained in two localities out of the seven analyzed, exhibited accumulation of galphimines. In the present work, we tested the hypothesis that this accumulation responds to genetic control. Galphimia sp. individuals were collected from six previously studied populations, located in five Mexican states (Doctor Mora in Guanajuato, Jalpan in Querétaro, Cuernavaca and Tepoztlán in Morelos, Guadalajara in Jalisco, and Tuxtla Gutiérrez in Chiapas), and transplanted to grow under uniform greenhouse conditions, for a period of 11 months. A phytochemical analysis using chromatographic procedures was performed for all individuals upon arrival and after 11 months of controlled growth. Results indicated that only two populations (Doctor Mora, Guanajuato, and Jalpan, Querétaro), out of the six that were collected, produced galphimines before and after controlled growth, exhibiting the same chemotype pattern in the greenhouse, as in the wild. However, evident changes in foliar morphology, probably due to phenotypic plasticity, were observed in all the acclimatized plants. [Figure not available: see fulltext.] © 2020, Sociedade Brasileira de Farmacognosia.
Filiaciones:
Balderas G.S.:
Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa, Morelos, Cuernavaca, 62209, Mexico
Alcalá R.E.:
Centro de Investigación en Biodiversidad y Conservación, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa, Morelos, Cuernavaca, 62209, Mexico
Ortíz-Caltempa A.:
Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa, Morelos, Cuernavaca, 62209, Mexico
Cardoso-Taketa A.:
Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa, Morelos, Cuernavaca, 62209, Mexico
Villarreal M.L.:
Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa, Morelos, Cuernavaca, 62209, Mexico
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