TNFSF4 is a risk factor for rheumatoid arthritis but not for primary Sjögren's syndrome in the Mexican population
Por:
Ramírez-Bello J., Jiménez-Morales S., Barbosa-Cobos R.E., Sánchez-Zauco N., Hernández-Molina G., Luria-Pérez R., Fragoso J.M., Cabello-Gutiérrez C., Montúfar-Robles I.
Publicada:
1 ene 2022
Resumen:
Purpose: Rheumatoid arthritis (RA) and primary Sjögren's syndrome (pSS) are autoimmune diseases (ADs) characterized by joint damage and involvement of the salivary glands, respectively. ADs share some susceptibility loci, such as TNFSF4, which is a classical susceptibility gene associated with systemic lupus erythematosus, but its role in RA and pSS is not yet clear. Thus, the aim of this study was to determine whether three TNFSFS4 polymorphisms are associated with RA and pSS. Methods: Our case-control study included 500 controls, 459 patients with RA, and 210 patients with pSS from Mexico. TNFSF4 single nucleotide polymorphisms (SNPs) rs1234315C/T, rs2205960G/T, and rs704840T/G were genotyped using TaqMan probes and discrimination allelic assay. Results: The three TNFSF4 SNPs were associated with susceptibility to RA (rs1234315C/T: odds ratio [OR] 1.4, p = 0.01; rs2205960G/T: OR 1.23, p = 0.03; rs704840T/G: OR 1.24, p = 0.02). An association between TNFSF4 rs1234315C/T and pSS was also observed (OR 1.28, p = 0.04), however, after Bonferroni correction, this association was lost. Conclusion: Our data suggest that TNFSF4 could be a risk factor in RA but not pSS in a Mexican population. © 2022
Filiaciones:
Ramírez-Bello J.:
Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, 14080, Mexico
Jiménez-Morales S.:
Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
Barbosa-Cobos R.E.:
Servicio de Reumatología, Hospital Juárez de México, Mexico City, 07760, Mexico
Sánchez-Zauco N.:
División de Auxiliares de Diagnóstico y Tratamiento, UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, 06720 IMSS, Mexico
Hernández-Molina G.:
Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, 14080, Mexico
Luria-Pérez R.:
Unidad de Investigación en Enfermedades Hemato-Oncológicas, Hospital Infantil de México Federico Gómez06720, Mexico
Fragoso J.M.:
Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, 14080, Mexico
Cabello-Gutiérrez C.:
Departamento de Investigación en Virología y Micología, Instituto Nacional de Enfermedades Respiratorias, Mexico City, 14080, Mexico
Montúfar-Robles I.:
Unidad de Investigación, Hospital Juárez de México, 07760, Mexico City, Mexico
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