Circadian modulation of microglial physiological processes and immune responses
Por:
Guzmán-Ruiz M.A., Guerrero-Vargas N.N., Lagunes-Cruz A., González-González S., García-Aviles J.E., Hurtado-Alvarado G., Mendez-Hernández R., Chavarría-Krauser A., Morin J.-P., Arriaga-Avila V., Buijs R.M., Guevara-Guzmán R.
Publicada:
1 ene 2023
Resumen:
Microglia is considered the central nervous system (CNS) resident macrophages that establish an innate immune response against pathogens and toxins. However, the recent studies have shown that microglial gene and protein expression follows a circadian pattern; several immune activation markers and clock genes are expressed rhythmically without the need for an immune stimulus. Furthermore, microglia responds to an immune challenge with different magnitudes depending on the time of the day. This review examines the circadian control of microglia function and the possible physiological implications. For example, we discuss that synaptic prune is performed in the cortex at a certain moment of the day. We also consider the implications of daily microglial function for maintaining biological rhythms like general activity, body temperature, and food intake. We conclude that the developmental stage, brain region, and pathological state are not the only factors to consider for the evaluation of microglial functions; instead, emerging evidence indicates that circadian time as an essential aspect for a better understanding of the role of microglia in CNS physiology. © 2022 The Authors. GLIA published by Wiley Periodicals LLC.
Filiaciones:
Guzmán-Ruiz M.A.:
Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, Mexico
Guerrero-Vargas N.N.:
Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, Mexico
Lagunes-Cruz A.:
Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, Mexico
González-González S.:
Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, Mexico
García-Aviles J.E.:
Área de Neurociencias, Departamento de Biología de la Reproducción, Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, México City, Mexico
Hurtado-Alvarado G.:
Instituto Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México City, Mexico
Mendez-Hernández R.:
Instituto Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México City, Mexico
Chavarría-Krauser A.:
Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, Mexico
Morin J.-P.:
Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, Mexico
Arriaga-Avila V.:
Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, Mexico
Buijs R.M.:
Instituto Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México City, Mexico
Guevara-Guzmán R.:
Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, Mexico
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