Impaired Carbohydrate Metabolism and Excess of Lipid Accumulation in Offspring of Hyperandrogenic Mice
Por:
Aburto-Hernandez, Cynthia, Barrera, David, Ortiz-Hernandez, Rosario, Espinoza-Simon, Emilio, Parra-Gamez, Leticia, Gonzalez, James, Escobar M.L., Vazquez-Nin, Gerardo H., Echeverria-Martinez, Olga, Torres-Ramirez, Nayeli
Publicada:
1 dic 2022
Resumen:
Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder of
unknown etiology. Hyperandrogenism (HA) is the main diagnostic criteria
for PCOS, in addition to being a risk factor for developing several
disorders throughout the patient's life, including pregnancy. However,
the impact on offspring is little known. Therefore, the aim of this work
was to evaluate the effect of maternal HA on glucose metabolism and
hepatic lipid accumulation in adult offspring. We used Balb/c mice
treated with dehydroepiandrosterone (DHEA) for 20 consecutive days. The
ovary of DHEA-treated mice showed hemorrhagic bodies, an increased
number of atretic follicles, and greater expression of genes related to
meiotic cell cycle and DNA repair. The DHEA offspring (O-DHEA) had low
birth weight, and some pups showed malformations. However, O-DHEA
individuals gained weight rapidly, and the differences between them and
the control group became significantly greater in adulthood. Moreover,
O-DHEA presented higher serum glucose after a 6 h fast and a larger area
under glucose, insulin, and pyruvate tolerance test curves. Oil Red O
staining showed a more significant accumulation of fat in the liver but
no changes in serum cholesterol and triacylglycerol levels. In summary,
our results show that HA, induced by DHEA, affects gene expression in
oocyte, which in turn generates defects in embryonic development,
insulin resistance, and alteration in hepatic gluconeogenesis and lipid
metabolism in O-DHEA, thereby increasing the risk of developing
metabolic diseases.
Filiaciones:
Aburto-Hernandez, Cynthia:
Departamento de Biología Celular, Facultad de Ciencias, Universidad Nacional Autónoma de Mexico, Avenida Universidad 3000, Cd. Universitaria, Coyoacán, Mexico City, 04510, Mexico
Barrera, David:
Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Av. Vasco de Quiroga No. 15, Col. Belisario Domínguez, Sección XVI, Mexico City, 14080, Mexico
Ortiz-Hernandez, Rosario:
Departamento de Biología Celular, Facultad de Ciencias, Universidad Nacional Autónoma de Mexico, Avenida Universidad 3000, Cd. Universitaria, Coyoacán, Mexico City, 04510, Mexico
Espinoza-Simon, Emilio:
Departamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Cd. Universitaria, Coyoacán, Mexico City, 04510, Mexico
Parra-Gamez, Leticia:
Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Cd. Universitaria, Coyoacán, Mexico City, 04510, Mexico
Gonzalez, James:
Departamento de Biología Celular, Facultad de Ciencias, Universidad Nacional Autónoma de Mexico, Avenida Universidad 3000, Cd. Universitaria, Coyoacán, Mexico City, 04510, Mexico
Escobar M.L.:
Departamento de Biología Celular, Facultad de Ciencias, Universidad Nacional Autónoma de Mexico, Avenida Universidad 3000, Cd. Universitaria, Coyoacán, Mexico City, 04510, Mexico
Vazquez-Nin, Gerardo H.:
Departamento de Biología Celular, Facultad de Ciencias, Universidad Nacional Autónoma de Mexico, Avenida Universidad 3000, Cd. Universitaria, Coyoacán, Mexico City, 04510, Mexico
Echeverria-Martinez, Olga:
Departamento de Biología Celular, Facultad de Ciencias, Universidad Nacional Autónoma de Mexico, Avenida Universidad 3000, Cd. Universitaria, Coyoacán, Mexico City, 04510, Mexico
Torres-Ramirez, Nayeli:
Departamento de Biología Celular, Facultad de Ciencias, Universidad Nacional Autónoma de Mexico, Avenida Universidad 3000, Cd. Universitaria, Coyoacán, Mexico City, 04510, Mexico
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