Neuropsychiatric Symptoms among Hispanics: Results of the Maracaibo Aging Study
Por:
Gil M., Alliey-Rodriguez N., Lopez-Alvarenga J.C., Diego V., Gaona C.A., Mata L., Pirela R.V., Chavez C.A., De Erausquin G.A., Melgarejo J.D., Maestre G.E.
Publicada:
1 ene 2021
Resumen:
Neuropsychiatric symptoms play an important role in diagnosing and clinical follow-up of cognitive impairment and dementia. Objective: We investigated the relationship between neuropsychiatric symptoms, cognitive impairment, and dementia in Hispanics. Methods: We included 529 participants (age =40 years) from the Maracaibo Aging Study with standardized neuropsychiatric assessments, including the Neuropsychiatric Inventory (NPI). Based on the Clinical Dementia Rating and the Mini-Mental State Examination scores, participants' cognitive status was categorized into normal cognition, mild/moderate, and severe cognitive impairment. Diagnosis of dementia was established in a consensus conference. Statistical analyses included multivariable logistic regression models and area under the curve (AUC). Results: The mean age of participants was 59.3 years, and 71.8%were women. The proportion of dementia was 6.8%. Disturbed sleep, anxiety, and depression were the most common neuropsychiatric symptoms in the study sample. In crude analyses, the proportions of hallucinations, aberrant motor behavior, agitation/aggression, apathy, delusions, irritability, eating disturbance, depression, and euphoria were differently distributed among cognitive status groups (p < 0.05). After accounting for confounders, aberrant motor behavior and agitation/aggression remained significantly associated with cognitive impairment and dementia (p < 0.05). The inclusion of the NPI domains significantly improved the AUC to discriminate severe cognitive impairment and dementia compared to a basic model that included sex, age, education, alcohol, obesity, serum glucose, total cholesterol, hypertension, and stroke. Conclusion: Neuropsychiatric symptoms are associated with severe cognitive impairment and dementia. The addition of NPI items to the global cognitive assessment might help early detection of dementia in primary care settings. © 2021 - IOS Press. All rights reserved.
Filiaciones:
Gil M.:
Department of Psychological Science, University of Texas Rio Grande Valley, Brownsville, TX, United States
Department of Neuroscience, School of Medicine, University of Texas Rio Grande Valley, Harlingen, TX, United States
Rio Grande Valley Alzheimer's Disease Resource, Center for Minority Aging Research (RGV AD-RCMAR), University of Texas Rio Grande Valley, Brownsville, TX, United States
Institute for Neuroscience, School of Medicine, University of Texas Rio Grande Valley, Harlingen, TX, United States
Alliey-Rodriguez N.:
Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, United States
Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States
Laboratory of Neurosciences, School of Medicine, University of Zulia, Maracaibo, Venezuela
Lopez-Alvarenga J.C.:
Rio Grande Valley Alzheimer's Disease Resource, Center for Minority Aging Research (RGV AD-RCMAR), University of Texas Rio Grande Valley, Brownsville, TX, United States
Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, United States
Som South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX, United States
Diego V.:
Rio Grande Valley Alzheimer's Disease Resource, Center for Minority Aging Research (RGV AD-RCMAR), University of Texas Rio Grande Valley, Brownsville, TX, United States
Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, United States
Som South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX, United States
Gaona C.A.:
Laboratory of Neurosciences, School of Medicine, University of Zulia, Maracaibo, Venezuela
Mata L.:
Laboratory of Neurosciences, School of Medicine, University of Zulia, Maracaibo, Venezuela
Pirela R.V.:
Rio Grande Valley Alzheimer's Disease Resource, Center for Minority Aging Research (RGV AD-RCMAR), University of Texas Rio Grande Valley, Brownsville, TX, United States
Laboratory of Neurosciences, School of Medicine, University of Zulia, Maracaibo, Venezuela
Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, United States
Chavez C.A.:
Laboratory of Neurosciences, School of Medicine, University of Zulia, Maracaibo, Venezuela
De Erausquin G.A.:
Department of Neurology, Long School of Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX, United States
Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX, United States
Melgarejo J.D.:
Laboratory of Neurosciences, School of Medicine, University of Zulia, Maracaibo, Venezuela
Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, Ku Leuven, Leuven, Belgium
Maestre G.E.:
Department of Neuroscience, School of Medicine, University of Texas Rio Grande Valley, Harlingen, TX, United States
Rio Grande Valley Alzheimer's Disease Resource, Center for Minority Aging Research (RGV AD-RCMAR), University of Texas Rio Grande Valley, Brownsville, TX, United States
Institute for Neuroscience, School of Medicine, University of Texas Rio Grande Valley, Harlingen, TX, United States
Laboratory of Neurosciences, School of Medicine, University of Zulia, Maracaibo, Venezuela
Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, United States
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