Loperamide exerts a direct bactericidal effect against M. tuberculosis, M. bovis, M. terrae and M. smegmatis
Por:
Barrientos O.M., Juárez E., Gonzalez Y., Castro-Villeda D.A., Torres M., Guzmán-Beltrán S.
Publicada:
1 ene 2021
Categoría:
Applied microbiology and biotechnology
Resumen:
Tuberculosis (TB) is caused by Mycobacterium tuberculosis. TB is highly prevalent, characterized by the constant occurrence of drug-resistant cases, and confounded by the incidence of respiratory disease caused by non-tuberculous mycobacteria (NTB). Expanding the spectrum of drugs for the treatment of TB is indispensable. Loperamide, an antidiarrhoeal drug, enhances immune-driven antimycobacterial activity, and we aimed to evaluate its bactericidal activity against M. tuberculosis, Mycobacterium bovis BCG, Mycobacterium terrae and Mycobacterium smegmatis. Loperamide exhibited an inhibitory effect against all mycobacterial species tested, with MICs of 100 and 150 µg ml-1. Thus, loperamide is a mycobactericidal drug with potential as adjunctive therapy for TB and NTB infections. © 2020 The Society for Applied Microbiology
Filiaciones:
Barrientos O.M.:
Departamento de Investigación en Microbiología, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico
Juárez E.:
Departamento de Investigación en Microbiología, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico
Gonzalez Y.:
Departamento de Investigación en Microbiología, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico
Castro-Villeda D.A.:
Departamento de Investigación en Microbiología, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico
Torres M.:
Subdireccion de Investigación, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, México City, Mexico
Guzmán-Beltrán S.:
Departamento de Investigación en Microbiología, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico
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