Effects of chronic taurine administration on healthy pregnant rats and the consequences on the offspring: Datasets for motor tests and oxidative stress
Por:
Vargas-Castro V., Gomez-Diaz R., Blanco-Alvarez V.M., Tomas-Sanchez C., Gonzalez-Vazquez A., Aguilar-Peralta A.K., Gonzalez-Barrios J.A., Martinez-Fong D., Eguibar J.R., Ugarte A., Soto-Rodriguez G., Brambila E., Millán-Perez Peña L., Leon-Chavez B.A.
Publicada:
1 ene 2022
Resumen:
We present the data for taurine (2-aminoethanesulfonic acid) treatment to healthy pregnant Sprague Dawley rats (SD). At embryonic day 15 (E15), healthy pregnant SD rats were given taurine treatment (50 mg/L drinking water) and then to their male offspring until they reached the age of eight months. We quantify, in the offspring, the concentration of nitric oxide (NO) through the Griess colorimetric reaction [1] and malondialdehyde + 4-hydroxyalkenals (MDA + 4-HDA) by the Gérard-Monnier technique [2]. The assessment ages for NO and MDA + 4-HDA were at postnatal day 15 (PND15), 1, 3, and 8 months of age. The body weight was measured along with the integral motor behavior in the perinatal stage through the surface righting reflex test at PND5, cliff aversion test at PND9, grip strength test at PND 11, and front limb and hindlimb suspension tests at PND13. The tests were performed accordingly with [3]. The data obtained showed that SD rats with the taurine administration performed poorly in the motor tests compared with the untreated healthy rats. The taurine-treated rats also showed increased lipid peroxidation preferentially in cerebral regions involved in motor activity, such as the medulla oblongata, the subcortical nuclei, and the cerebral cortex. However, the taurine treatment only increased NO concentration in the evaluated cerebral regions at older ages. At E15, taurine plays a pivotal role in the excitatory/inhibitory neuromodulation, presumably by acting as an excitatory neurotransmitter during the GABA-switch [4]. The increase in the taurine concentration during the embryonic period might cause excitotoxicity in healthy brains, which might lead to impairments in the motor development of the offspring. Therefore, the present datasets can be valuable for researchers who attempt to use the taurine supplement on healthy animal models at gestational stages; and explore the relation with taurine intake during pregnancy in human patients. These datasets are related to the article “Long-term taurine administration improves motor skills in a tubulinopathy rat model by decreasing oxidative stress and promoting myelination” [5]. © 2022
Filiaciones:
Vargas-Castro V.:
Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, C. P. 72570, Mexico
Gomez-Diaz R.:
Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, C. P. 72570, Mexico
Blanco-Alvarez V.M.:
Facultad de Enfermería, Benemérita Universidad Autónoma de Puebla, Puebla, C. P. 72304, Mexico
Tomas-Sanchez C.:
Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, C. P. 72570, Mexico
Gonzalez-Vazquez A.:
Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, C. P. 72570, Mexico
Aguilar-Peralta A.K.:
Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, C. P. 72570, Mexico
Gonzalez-Barrios J.A.:
Laboratorio de Medicina Genómica, Hospital Regional 1º de Octubre, ISSSTE, Mexico City, C. P. 07760, Mexico
Martinez-Fong D.:
Departamento de Fisiología, Biofísica y Neurociencias, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Apartado Postal 14-740, Mexico City, C. P. 07000, Mexico
Nanoparticle Therapy Institute 404 Avenida Monte Blanco Aguascalientes, Aguascalientes, C.P. 20120, México., Aguascalientes, C.P. 20120, Mexico
Eguibar J.R.:
Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, PU, Puebla, C. P. 72570, Mexico
Ugarte A.:
Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, PU, Puebla, C. P. 72570, Mexico
Soto-Rodriguez G.:
Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, PU, Puebla, C. P. 72304, Mexico
Brambila E.:
Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, C. P. 72570, Mexico
Millán-Perez Peña L.:
Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, C. P. 72570, Mexico
Leon-Chavez B.A.:
Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, C. P. 72570, Mexico
Gold
|