The rs8176740 T/A and rs512770 T/C Genetic Variants of the ABO Gene Increased the Risk of COVID-19, as well as the Plasma Concentration Platelets
Por:
Vargas-Alarcón G., Ramírez-Bello J., Posadas-Sánchez R., Rojas-Velasco G., López-Reyes A., Martínez-Gómez L., Ortega-Peña S., Montúfar-Robles I., Barbosa-Cobos R.E., Arellano-González M., Fragoso J.M.
Publicada:
1 ene 2022
Resumen:
We conducted a case-control study in order to evaluate whether ABO gene polymorphisms were associated with a high risk of developing COVID-19 in a cohort of patients. Six ABO gene polymorphisms (rs651007 T/C, rs579459 T/C, rs495828 T/G, rs8176746 A/C, rs8176740 T/A, and rs512770 T/C) were determined using TaqMan genotyping assays in a group of 415 COVID-19 patients and 288 healthy controls. The distribution of rs651007 T/C, rs579459 T/C, rs495828 T/G, and rs8176746 A/C polymorphisms was similar in patients and healthy controls. Nonetheless, under co-dominant (OR = 1.89, pCCo-dominant = 6 × 10-6 ), recessive (OR = 1.98, pCRecessive = 1 × 10-4), and additive (OR = 1.36, pCAdditive = 3 × 10-3 ) models, the TT genotype of the rs8176740 T/A polymorphism increased the risk of developing COVID-19. In the same way, under co-dominant, recessive, and additive models, the TT genotype of the rs512770 T/C polymorphism was associated with a high risk of developing COVID-19 (OR = 1.87, pCCo-dominant = 2 × 10-3; OR = 1.87, pCRecessive = 5 × 10-4; and OR = 1.35, pCAdditive = 4 × 10-3, respectively). On the other hand, the GTC and GAT haplotypes were associated with a high risk of COVID-19 (OR = 5.45, pC = 1 × 10-6 and OR = 6.33, pC = 1 × 10-6, respectively). In addition, the rs8176740 TT genotype was associated with high-platelet plasma concentrations in patients with COVID-19. Our data suggested that the ABO rs512770 T/C and rs8176740 T/A polymorphisms increased the risk of developing COVID-19 and the plasma concentration of platelets. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Filiaciones:
Vargas-Alarcón G.:
Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, 14080, Mexico
Ramírez-Bello J.:
Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, 14080, Mexico
Posadas-Sánchez R.:
Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, 14080, Mexico
Rojas-Velasco G.:
Intensive Care Unit, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, 14080, Mexico
López-Reyes A.:
Laboratory of Gerosciences, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Mexico City, 14289, Mexico
Martínez-Gómez L.:
Laboratory of Gerosciences, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Mexico City, 14289, Mexico
Ortega-Peña S.:
Laboratory of Gerosciences, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Mexico City, 14289, Mexico
Montúfar-Robles I.:
Research Unit, Hospital Juárez de México, Mexico City, 07760, Mexico
Barbosa-Cobos R.E.:
Rheumatology Service, Hospital Juárez de México, Mexico City, 07760, Mexico
Arellano-González M.:
Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, 14080, Mexico
Fragoso J.M.:
Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, 14080, Mexico
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