A(H3N2) antigenic variation of influenza is associated with low vaccine efficacy in the early 2018 influenza season in Mexico City
Por:
Hernandez-Hernandez, Victor Alberto, Higuera-Iglesias, Anjarath Lorena, Palma-Cortes, Gabriel, Tapia-Trejo, Daniela, Avila-Rios, Santiago, Gonzalez-Fernandez, Ruben Roberto, Perez-Moreno, Luis Angel, Zuñiga-Ramos J.A., Guadarrama-Perez, Cristobal, Sandoval-Gutierrez, Jose Luis, Cabello-Gutierrez, Carlos
Publicada:
1 ene 2022
Resumen:
Objectives: We evaluated the VE and the mutations of the viruses present in the Mexican population at the beginning of 2018. Methods: We diagnosed influenza in outpatients with a high-performance Rapid Influenza Diagnostic Test (RIDT) qRT–PCR. Descriptive statistics were used to describe the study population, while the chi-square test was used to determine clinical variables. VE was analyzed through a negative test design. We sequenced the hemagglutinin (HA) gene, performed a phylogenetic analysis, and analyzed the nonsynonymous substitutions both in and outside antigenic sites. Results: Of the 240 patients analyzed, 42.5% received the trivalent vaccine, and 37.5% were positive for influenza. The VE for the general population for any influenza virus type or subtype was 37.0%, while the VE for the predominant influenza A(H3N2) subtype was the lowest (19.7%). The phylogenetic analysis of HA showed the co-circulation of clades and subclades 3C.2a1, 3C.2a1b, 3C.2a2, 3C.2a2re, 3C.2a3, and 3C.3a with identities approximately 97-98% similar to the vaccine composition. Conclusion: Low VE was related to the co-circulation of multiple clades and subclades of influenza A(H3N2), with sufficient genetic and phenotypic distance to allow for the infection of vaccinated individuals. © 2022 The Author(s)
Filiaciones:
Hernandez-Hernandez, Victor Alberto:
National Institute of Respiratory Diseases “Ismael Cosio Villegas” (INER), Department of Research in Virology and Mycology, Mexico City, Mexico
National Autonomous University of Mexico, Postgraduate in Biological Sciences, Faculty of Medicine, Mexico City, Mexico
Higuera-Iglesias, Anjarath Lorena:
National Institute of Respiratory Diseases “Ismael Cosio Villegas” (INER), Research in Clinical Epidemiology, Mexico City, Mexico
Palma-Cortes, Gabriel:
National Institute of Respiratory Diseases “Ismael Cosio Villegas” (INER), Department of Research in Virology and Mycology, Mexico City, Mexico
Tapia-Trejo, Daniela:
National Institute of Respiratory Diseases “Ismael Cosio Villegas” (INER), Infectious Disease Research Center, Mexico City, Mexico
Avila-Rios, Santiago:
National Institute of Respiratory Diseases “Ismael Cosio Villegas” (INER), Infectious Disease Research Center, Mexico City, Mexico
Gonzalez-Fernandez, Ruben Roberto:
National Institute of Respiratory Diseases “Ismael Cosio Villegas” (INER), Department of Research in Virology and Mycology, Mexico City, Mexico
Perez-Moreno, Luis Angel:
National Institute of Respiratory Diseases “Ismael Cosio Villegas” (INER), Department of Research in Virology and Mycology, Mexico City, Mexico
Zuñiga-Ramos J.A.:
National Institute of Respiratory Diseases “Ismael Cosio Villegas” (INER), Immunobiology and Genetics Laboratory, Mexico City, Mexico
Tecnologico de Monterrey, School of Medicine and Health Sciences, Mexico City, Mexico
Guadarrama-Perez, Cristobal:
National Institute of Respiratory Diseases “Ismael Cosio Villegas” (INER), Institutional Influenza Committee, Mexico City, Mexico
Sandoval-Gutierrez, Jose Luis:
National Institute of Respiratory Diseases “Ismael Cosio Villegas” (INER), Institutional Influenza Committee, Mexico City, Mexico
Cabello-Gutierrez, Carlos:
National Institute of Respiratory Diseases “Ismael Cosio Villegas” (INER), Department of Research in Virology and Mycology, Mexico City, Mexico
Gold
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