Evidence of possible SARS-CoV-2 vertical transmission according to World Health Organization criteria in asymptomatic pregnant women
Por:
Sevilla-Montoya R., Hidalgo-Bravo A., Estrada-Gutiérrez G., Villavicencio-Carrisoza O., Leon-Juarez M., Villegas-Mota I., Espino-Y-sosa S., Monroy-Muñoz I.E., Martinez-Portilla R.J., Poon L.C., Cardona-Pérez J.A., Helguera-Repetto A.C., Gonzalez-García L.D., Mora-Vargas C.D., Mateu-Rogell P., Rodriguez-Bosch M., Coronado-Zarco I., Acevedo-Gallegos S., Aguinaga-Ríos M., Ramirez-Santes V.H., Ortiz-Ramirez M.A., Valdes-Flores M., Cortes-Bonilla M.
Publicada:
1 ene 2021
Resumen:
Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vertical transmission has been investigated extensively. Recently, the World Health Organization (WHO) published strict criteria to classify the timing of mother-to-child transmission of SARS-CoV-2 into different categories. The aim of this study was to investigate the possibility of vertical transmission in asymptomatic SARS-CoV-2-positive women. Methods: Pregnant women attending for delivery at a perinatology center in Mexico City, Mexico, who had a SARS-CoV-2-positive nasopharyngeal swab 24–48 h before delivery, were asymptomatic at the time of the test and had an obstetric indication for Cesarean section were eligible for inclusion in this study. Amniotic fluid was collected during Cesarean delivery, and neonatal oral and rectal swabs were collected at birth and at 24 h after birth. SARS-CoV-2 detection was carried out using real-time reverse-transcription polymerase chain reaction in all samples. Relevant medical information was retrieved from clinical records. The WHO criteria for classifying the timing of mother-to-child transmission of SARS-CoV-2 were applied to the study population. Results: Forty-two SARS-CoV-2-positive asymptomatic pregnant women fulfilled the inclusion criteria. Twenty-five (59%) women developed mild disease after discharge. Neonatal death occurred in three (7%) cases, of which one had a positive SARS-CoV-2 test at birth and none had coronavirus disease 2019-related symptoms. There were five (12%) cases with strong evidence of intrauterine transmission of SARS-CoV-2, according to the WHO criteria, as amniotic fluid samples and neonatal samples at birth and at 24 h after birth were positive for SARS-CoV-2. Our results also showed that 40–60% of infected neonates would have been undetected if only one swab (oral or rectal) was tested. Conclusion: This study contributes evidence to reinforce the potential for vertical transmission of SARS-CoV-2 even in asymptomatic women and highlights the importance of testing more than one neonatal sample in order to increase the detection rate of SARS-CoV-2 in affected cases. © 2021 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. © 2021 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Filiaciones:
Sevilla-Montoya R.:
Department of Genetics and Human Genomics, National Institute of Perinatology, Mexico City, Mexico
Hidalgo-Bravo A.:
Department of Genetics and Genomic Medicine, National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra, Mexico City, Mexico
Estrada-Gutiérrez G.:
Dirección de Investigación, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico
Villavicencio-Carrisoza O.:
Departamento de Inmuno-Bioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico
Programa de posgrado en Biomedicina y Biotecnología Molecular, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Mexico City, Mexico
Leon-Juarez M.:
Departamento de Inmuno-Bioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico
Villegas-Mota I.:
Unidad de Enfermedades Infecciosas y Epidemiología, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico
Espino-Y-sosa S.:
Subdirección de Investigación Clínica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico
Monroy-Muñoz I.E.:
Department of Genetics and Human Genomics, National Institute of Perinatology, Mexico City, Mexico
Martinez-Portilla R.J.:
Subdirección de Investigación Clínica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico
Poon L.C.:
Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
Cardona-Pérez J.A.:
Dirección General, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico
Helguera-Repetto A.C.:
Departamento de Inmuno-Bioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico
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