Are overweight and obesity risk factors for invasive mechanical ventilation in severe coronavirus disease 2019 pneumonia?
Por:
Coss-Rovirosa M.F., Aguilar-Soto M., Cuenca D., Velez-Pintado M., Camiro-Zuñiga A., Ferreira-Hermosillo A., Mercado M.
Publicada:
1 ene 2021
Categoría:
Endocrinology, diabetes and metabolism
Resumen:
Objective: Describe the demographic, clinical, and biochemical characteristics of overweight or obese people with severe COVID-19 pneumonia and evaluate its association with mechanical ventilation requirements in a Mexican cohort. Methods: Data were obtained from medical electronic records. Patients were divided in three groups according to the World Health Organization (WHO) classification of body mass index (BMI): lean, overweight and obese. Baseline characteristics and clinical course were compared among these 3 groups. Results: The study included a total of 355 patients with confirmed COVID-19 diagnoses. Patients with obesity and overweigh, according to the WHO classification, had no significantly increased risk of requiring intubation and invasive mechanical ventilation (IMV) compared to lean subjects, with an odds ratio (OR) of 1.82 (95% CI, 0.94-3.53). A post hoc and multivariate analysis using a BMI > 35 kg/m2 to define obesity revealed that subjects above this cut off had as significantly increased risk of requiring IMV after with an OR of 2.86 (95% CI, 1.09-7.05). Conclusion: We found no higher risk of requiring IMV in patients with overweight or obesity while using conventional BMI cutoffs. According to our sensitivity analyses, the risk of IMV increases in patients with a BMI over 35 kg/m2.
Filiaciones:
Coss-Rovirosa M.F.:
Department of Internal Medicine, American British Cowdray Medical CenterMexico City, Mexico
Aguilar-Soto M.:
Department of Internal Medicine, American British Cowdray Medical CenterMexico City, Mexico
Cuenca D.:
Department of Internal Medicine, American British Cowdray Medical CenterMexico City, Mexico
Velez-Pintado M.:
Department of Internal Medicine, American British Cowdray Medical CenterMexico City, Mexico
Camiro-Zuñiga A.:
Department of Internal Medicine, American British Cowdray Medical CenterMexico City, Mexico
Ferreira-Hermosillo A.:
Research Unit in Endocrine Diseases, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXIMexico City, Mexico
Mercado M.:
Research Unit in Endocrine Diseases, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXIMexico City, Mexico
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