Higher Veterans Aging Cohort Study 2.0 Index Score Predicts Functional Decline among Older Adults Living with HIV


Por: Hernández-Favela C.G., Hernández-Ruiz V.A., Bello-Chavolla O.Y., Crabtree-Ramírez B., Sierra-Madero J., Amieva H., Erlandson K.M., Avila-Funes J.A.

Publicada: 1 ene 2021
Resumen:
Living with HIV has been proposed as a risk factor for the early development of functional decline. Composite marker tools like the Veterans Aging Cohort Study (VACS) Index, which includes HIV-associated and non-HIV-related markers of disease may better reflect multiorgan system injury and potentially predict functional outcomes. Therefore, the objective of this work is to determine whether higher VACS 2.0 Index scores predicts functional decline among older adults living with HIV (OALWH). Longitudinal study, including 131 adults ages 50 or older who underwent a comprehensive geriatric assessment at baseline and follow-up, at least a year apart. Functional status was determined by the gait speed (seconds for a 4-m distance). Linear regression models were constructed to determine the relationship between VACS 2.0 Index at baseline with gait speed at follow-up adjusted for potential confounders. The median for age was 58.0 years (range 50-84), and 81.7% were male. At baseline, the median VACS 2.0 Index score was 50.4 (interquartile range 42.2-65.3). The adjusted linear regression analysis found that higher baseline VACS 2.0 Index scores were significantly associated with a decline in gait speed (p = .033) at follow-up. The results suggest that the VACS 2.0 Index works as a predictor of functional decline as showed by decline in gait speed and might serve as an easy tool to identify OALWH who might need additional resources or interventions to prevent it. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021.

Filiaciones:
Hernández-Favela C.G.:
 Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, Mexico City, CP 14080, Mexico

Hernández-Ruiz V.A.:
 Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, Mexico City, CP 14080, Mexico

 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France

Bello-Chavolla O.Y.:
 Instituto Nacional de Geriatriá, Mexico City, Mexico

Crabtree-Ramírez B.:
 Department de Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

Sierra-Madero J.:
 Department de Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

Amieva H.:
 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France

Erlandson K.M.:
 Division of Infectious Diseases and Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States

Avila-Funes J.A.:
 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France

 Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, Mexico City, CP 14080, Mexico
ISSN: 08892229
Editorial
MARY ANN LIEBERT, INC, 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 37 Número: 11
Páginas: 878-883
WOS Id: 000698776600001
ID de PubMed: 34465139

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