Thyroid stimulating hormone levels and geriatric syndromes: secondary nested case–control study of the Mexican Health and Aging Study
Por:
Perez-Zepeda M.U., Almeda-Valdes P., Fernandez-Villa J.M., Gomez-Arteaga R.C., Borda M.G., Cesari M.
Publicada:
1 ene 2022
Resumen:
Purpose: To determine the incidence of geriatric syndromes (GS) in community dwelling older adults with subclinical hypothyroidism. Methods: This is an analysis from the Mexican Health and Aging Study, of a subsample of 2089 subjects with TSH determination. From this last subsample, we included 1628 individuals with TSH levels in the subclinical range (4.5–10 µU/ml). Results: The multivariate analysis showed that when comparing data obtained from the 2012 wave with the 2015 wave results, there was a significant incidence of some GS such as falls (OR 1.79, CI 1.16–2.77, p = 0.0116), fatigue (OR 2.17, CI 1.40–3.38, p = 0.0348) and depression (OR 1.70, CI 1.06–2.71, p = 0.0246) among the subclinical hypothyroidism group. Conclusion: This study showed a greater incidence of GS in subjects 50 years and older with sub-clinical hypothyroidism, when compared to those with normal thyroid function. © 2021, The Author(s), under exclusive licence to European Geriatric Medicine Society.
Filiaciones:
Perez-Zepeda M.U.:
Research Department, INGER Instituto Nacional de Geriatria, Mexico City, Mexico
Health Sciences Research Center (CICSA), FCS, Universidad Anahuac Mexico Campus Norte, Edo. de Mexico, Mexico City, Mexico
Almeda-Valdes P.:
Research Center of Metabolic Diseases, Instituto Nacional de Ciencias Medicas Y Nutricion Salvador Zubiran, Mexico City, Mexico
Fernandez-Villa J.M.:
Red Tematica de Envejecimiento Salud y Desarrollo Social, CONACyT, Mexico City, Mexico
Gomez-Arteaga R.C.:
Clinica del Country-Hospital Universitario San Ignacio, Bogota, Colombia
Borda M.G.:
Semillero de Neurociencias y Envejecimiento, Instituto de Envejecimiento, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia
Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway
Cesari M.:
Geriatric Unit, IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy
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