Predominance of antibody-resistant SARS-CoV-2 variants in vaccine breakthrough cases from the San Francisco Bay Area, California
Por:
Servellita V., Morris M.K., Sotomayor-Gonzalez A., Gliwa A.S., Torres E., Brazer N., Zhou A., Hernandez K.T., Sankaran M., Wang B., Wong D., Wang C., Zhang Y., Reyes K.R., Glasner D., Deng X., Streithorst J., Miller S., Frias E., Rodgers M., Cloherty G., Hackett J., Jr., Hanson C., Wadford D., Philip S., Topper S., Sachdev D., Chiu C.Y.
Publicada:
1 ene 2022
Resumen:
Associations between vaccine breakthrough cases and infection by different SARS coronavirus 2 (SARS-CoV-2) variants have remained largely unexplored. Here we analysed SARS-CoV-2 whole-genome sequences and viral loads from 1,373 persons with COVID-19 from the San Francisco Bay Area from 1 February to 30 June 2021, of which 125 (9.1%) were vaccine breakthrough infections. Vaccine breakthrough infections were more commonly associated with circulating antibody-resistant variants carrying =1 mutation associated with decreased antibody neutralization (L452R/Q, E484K/Q and/or F490S) than infections in unvaccinated individuals (78% versus 48%, P = 1.96 × 10-8). Differences in viral loads were non-significant between unvaccinated and fully vaccinated cases overall (P = 0.99) and according to lineage (P = 0.09–0.78). Symptomatic vaccine breakthrough infections had comparable viral loads (P = 0.64), whereas asymptomatic breakthrough infections had decreased viral loads (P = 0.023) compared with infections in unvaccinated individuals. In 5 cases with serial samples available for serologic analyses, vaccine breakthrough infections were found to be associated with low or undetectable neutralizing antibody levels attributable to an immunocompromised state or infection by an antibody-resistant lineage. Taken together, our results show that vaccine breakthrough infections are overrepresented by antibody-resistant SARS-CoV-2 variants, and that symptomatic breakthrough infections may be as efficient in spreading COVID-19 as unvaccinated infections, regardless of the infecting lineage. © 2022, The Author(s), under exclusive licence to Springer Nature Limited.
Filiaciones:
Servellita V.:
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States
UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, United States
Morris M.K.:
Viral and Rickettsial Disease Laboratory, California Department of Public Health, Richmond, CA, United States
Sotomayor-Gonzalez A.:
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States
UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, United States
Gliwa A.S.:
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States
UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, United States
Torres E.:
Color Genomics, Inc., Burlingame, CA, United States
Brazer N.:
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States
UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, United States
Zhou A.:
Color Genomics, Inc., Burlingame, CA, United States
Hernandez K.T.:
San Francisco Department of Public Health, San Francisco, CA, United States
Sankaran M.:
San Francisco Department of Public Health, San Francisco, CA, United States
Wang B.:
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States
UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, United States
Wong D.:
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States
UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, United States
Wang C.:
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States
UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, United States
Zhang Y.:
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States
UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, United States
Reyes K.R.:
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States
UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, United States
Glasner D.:
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States
UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, United States
Deng X.:
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States
UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, United States
Streithorst J.:
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States
UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, United States
Miller S.:
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States
UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, United States
Frias E.:
Abbott Laboratories, Abbott Park, IL, United States
Rodgers M.:
Abbott Laboratories, Abbott Park, IL, United States
Cloherty G.:
Abbott Laboratories, Abbott Park, IL, United States
Hackett J.:
Abbott Laboratories, Abbott Park, IL, United States
Jr.:
Abbott Laboratories, Abbott Park, IL, United States
Hanson C.:
Viral and Rickettsial Disease Laboratory, California Department of Public Health, Richmond, CA, United States
Wadford D.:
Viral and Rickettsial Disease Laboratory, California Department of Public Health, Richmond, CA, United States
Philip S.:
San Francisco Department of Public Health, San Francisco, CA, United States
Topper S.:
Color Genomics, Inc., Burlingame, CA, United States
Sachdev D.:
San Francisco Department of Public Health, San Francisco, CA, United States
Chiu C.Y.:
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States
UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, United States
Department of Medicine, University of California San Francisco, San Francisco, CA, United States
Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, United States
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