Absence of fluoride varnish-related adverse events in caries prevention trials in young children, United States
Por:
Garcia R.I., Gregorich S.E., Ramos-Gomez F., Braun P.A., Wilson A., Albino J., Tiwari T., Harper M., Batliner T.S., Rasmussen M., Cheng N.F., Santo W., Geltman P.L., Henshaw M., Gansky S.A.
Publicada:
1 ene 2017
Resumen:
Introduction Fluoride varnish is an effective prevention intervention for caries in young children. Its routine use in clinical care is supported by meta-analysesand recommended by clinical guidelines, including the US Preventive Services Task Force (B rating). This report is the first prospective systematic assessment of adverse events related to fluoride varnish treatment in young children. Methods We determined the incidence of adverse events related to fluoride varnish treatment in 3 clinical trials on the prevention of early childhood caries, conducted under the auspices of the Early Childhood Caries Collaborating Centers, an initiative sponsored by the National Institute of Dental and Craniofacial Research. Each trial incorporated use of fluoride varnish in its protocol and systematically queried all children's parents or legal guardians about the occurrence of acute adverse events after each fluoride varnish treatment. Results A total of 2,424community-dwelling,dentate children aged 0 to 5 years were enrolled and followed for up to 3 years. These children received a cumulative total of 10,249 fluoride varnish treatments. On average, each child received 4.2 fluoride varnish treatments. We found zero fluoride varnish-related adverse events. Conclusion Fluoride varnish was not associated with treatment-related adverse events in young children. Our findings support its safety as an effective prevention intervention for caries in young children.
Filiaciones:
Garcia R.I.:
Center for Research to Evaluate and Eliminate Dental Disparities, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, United States
Gregorich S.E.:
Center to Address Disparities in Children's Oral Health, School of Dentistry, University of California, San Francisco, United States
Department of Medicine, School of Medicine, University of California, San Francisco, United States
Ramos-Gomez F.:
School of Dentistry, University of California, Los Angeles, United States
Braun P.A.:
Center for Native Oral Health Research, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, United States
Wilson A.:
School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States
Albino J.:
Center for Native Oral Health Research, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, United States
Tiwari T.:
School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States
Harper M.:
Center for Native Oral Health Research, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, United States
Batliner T.S.:
Center for Native Oral Health Research, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, United States
Rasmussen M.:
Center to Address Disparities in Children's Oral Health, School of Dentistry, University of California, San Francisco, United States
Cheng N.F.:
Center to Address Disparities in Children's Oral Health, School of Dentistry, University of California, San Francisco, United States
Santo W.:
Center to Address Disparities in Children's Oral Health, School of Dentistry, University of California, San Francisco, United States
Geltman P.L.:
Center for Research to Evaluate and Eliminate Dental Disparities, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, United States
Henshaw M.:
Center for Research to Evaluate and Eliminate Dental Disparities, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, United States
Gansky S.A.:
Center to Address Disparities in Children's Oral Health, School of Dentistry, University of California, San Francisco, United States
Bronze
|