Valproic acid restricts mast cell activation by Listeria monocytogenes
Por:
Soria-Castro, Rodolfo, Meneses-Preza, Yatsiri G., Rodriguez-Lopez, Gloria M., Ibarra-Sanchez, Alfredo, Gonzalez-Espinosa, Claudia, Perez-Tapia, Sonia M., Flores-Borja, Fabian, Estrada-Parra, Sergio, Chavez-Blanco, Alma D., Chacon-Salinas, Rommel
Publicada:
20 sep 2022
Categoría:
Multidisciplinary
Resumen:
Mast cells (MC) play a central role in the early containment of
bacterial infections, such as that caused by Listeria monocytogenes
(L.m). The mechanisms of MC activation induced by L.m infection are well
known, so it is possible to evaluate whether they are susceptible to
targeting and modulation by different drugs. Recent evidence indicates
that valproic acid (VPA) inhibits the immune response which favors L.m
pathogenesis in vivo. Herein, we examined the immunomodulatory effect of
VPA on L.m-mediated MC activation. To this end, bone marrow-derived mast
cells (BMMC) were pre-incubated with VPA and then stimulated with L.m.
We found that VPA reduced MC degranulation and cytokine release induced
by L.m. MC activation during L.m infection relies on Toll-Like Receptor
2 (TLR2) engagement, however VPA treatment did not affect MC TLR2 cell
surface expression. Moreover, VPA was able to decrease MC activation by
the classic TLR2 ligands, peptidoglycan and lipopeptide Pam3CSK4. VPA
also reduced cytokine production in response to Listeriolysin O (LLO),
which activates MC by a TLR2-independent mechanism. In addition, VPA
decreased the activation of critical events on MC signaling cascades,
such as the increase on intracellular Ca2+ and phosphorylation of p38,
ERK1/2 and -p65 subunit of NF-kappa B. Altogether, our data demonstrate
that VPA affects key cell signaling events that regulate MC activation
following L.m infection. These results indicate that VPA can modulate
the functional activity of different immune cells that participate in
the control of L.m infection.
Filiaciones:
Soria-Castro, Rodolfo:
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional (ENCB-IPN), Carpio Y Plan de Ayala S/N Col. Santo Tomás, Mexico City, C.P. 11340, Mexico
Inst Politecn Nacl ENCB IPN, Dept Inmunol, Escuela Nacl Ciencias Biol, Carpio & Plan De Ayala S-N Col Santo Tomas, Mexico City 11340, DF, Mexico
Meneses-Preza, Yatsiri G.:
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional (ENCB-IPN), Carpio Y Plan de Ayala S/N Col. Santo Tomás, Mexico City, C.P. 11340, Mexico
Inst Politecn Nacl ENCB IPN, Dept Inmunol, Escuela Nacl Ciencias Biol, Carpio & Plan De Ayala S-N Col Santo Tomas, Mexico City 11340, DF, Mexico
Rodriguez-Lopez, Gloria M.:
Departamento de Microbiología e Inmunología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Dept Microbiol & Inmunol, Mexico City, DF, Mexico
Ibarra-Sanchez, Alfredo:
Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados (Cinvestav), Unidad Sede Sur, Mexico City, Mexico
Ctr Invest & Estudios Avanzados Cinvestav, Dept Farmacobiol, Unidad Sede Sur, Mexico City, DF, Mexico
Gonzalez-Espinosa, Claudia:
Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados (Cinvestav), Unidad Sede Sur, Mexico City, Mexico
Ctr Invest & Estudios Avanzados Cinvestav, Dept Farmacobiol, Unidad Sede Sur, Mexico City, DF, Mexico
Perez-Tapia, Sonia M.:
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional (ENCB-IPN), Carpio Y Plan de Ayala S/N Col. Santo Tomás, Mexico City, C.P. 11340, Mexico
Unidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional (ENCB-IPN), Mexico City, Mexico
Inst Politecn Nacl ENCB IPN, Dept Inmunol, Escuela Nacl Ciencias Biol, Carpio & Plan De Ayala S-N Col Santo Tomas, Mexico City 11340, DF, Mexico
Inst Politecn Nacl ENCB IPN, Escuela Nacl Ciencias Biol, Unidad Desarrollo & Invest Bioproc UDIBI, Mexico City, DF, Mexico
Flores-Borja, Fabian:
Centre for Oral Immunobiology and Regenerative Medicine, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Queen Mary Univ London, Ctr Oral Immunobiol & Regenerat Med, Barts & London Sch Med & Dent, London, England
Estrada-Parra, Sergio:
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional (ENCB-IPN), Carpio Y Plan de Ayala S/N Col. Santo Tomás, Mexico City, C.P. 11340, Mexico
Inst Politecn Nacl ENCB IPN, Dept Inmunol, Escuela Nacl Ciencias Biol, Carpio & Plan De Ayala S-N Col Santo Tomas, Mexico City 11340, DF, Mexico
Chavez-Blanco, Alma D.:
Subdirección de Investigación Básica, Instituto Nacional de Cancerología (INCan), Av. San Fernando No. 22. Col. Sección XVI, México City, C.P. 14080, Mexico
Inst Nacl Cancerol INCan, Subdirecc Invest Basica, Av San Fernando 22 Col Secc 16, Mexico City 14080, DF, Mexico
Chacon-Salinas, Rommel:
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional (ENCB-IPN), Carpio Y Plan de Ayala S/N Col. Santo Tomás, Mexico City, C.P. 11340, Mexico
Inst Politecn Nacl ENCB IPN, Dept Inmunol, Escuela Nacl Ciencias Biol, Carpio & Plan De Ayala S-N Col Santo Tomas, Mexico City 11340, DF, Mexico
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