Inflammation: A Target for Treatment in Spinal Cord Injury
Por:
Freyermuth-Trujillo, Ximena, Segura-Uribe, Julia J., Salgado-Ceballos, Hermelinda, Orozco-Barrios, Carlos E., Coyoy-Salgado, Angelica
Publicada:
1 sep 2022
Categoría:
Biochemistry, genetics and molecular biology (miscellaneous)
Resumen:
Spinal cord injury (SCI) is a significant cause of disability, and
treatment alternatives that generate beneficial outcomes and have no
side effects are urgently needed. SCI may be treatable if intervention
is initiated promptly. Therefore, several treatment proposals are
currently being evaluated. Inflammation is part of a complex
physiological response to injury or harmful stimuli induced by
mechanical, chemical, or immunological agents. Neuroinflammation is one
of the principal secondary changes following SCI and plays a crucial
role in modulating the pathological progression of acute and chronic
SCI. This review describes the main inflammatory events occurring after
SCI and discusses recently proposed potential treatments and therapeutic
agents that regulate inflammation after insult in animal models.
Filiaciones:
Freyermuth-Trujillo, Ximena:
Inst Mexicano Seguro Social, Ctr Med Nacl Siglo XXI, Hosp Especialidades Dr Bernardo Sepulveda, Unidad Invest Med Enfermedades Neurol, Mexico City 06720, DF, Mexico
Univ Nacl Autonoma Mexico, Ciencias Biol, Mexico City 04510, DF, Mexico
Segura-Uribe, Julia J.:
Hosp Infantil Mexico Dr Federico Gomez, Secretaria Salud, Subdirecc Gest Invest, Mexico City 06720, DF, Mexico
Salgado-Ceballos, Hermelinda:
Inst Mexicano Seguro Social, Ctr Med Nacl Siglo XXI, Hosp Especialidades Dr Bernardo Sepulveda, Unidad Invest Med Enfermedades Neurol, Mexico City 06720, DF, Mexico
Orozco-Barrios, Carlos E.:
Inst Mexicano Seguro Social, Ctr Med Nacl Siglo XXI, Hosp Especialidades Dr Bernardo Sepulveda, CONACyT Unidad Invest Med Enfermedades Neurol, Mexico City 06720, DF, Mexico
Coyoy-Salgado, Angelica:
Inst Mexicano Seguro Social, Ctr Med Nacl Siglo XXI, Hosp Especialidades Dr Bernardo Sepulveda, CONACyT Unidad Invest Med Enfermedades Neurol, Mexico City 06720, DF, Mexico
gold, Gold
|